Targeting Attenuated Interferon-α to Myeloma Cells with a CD38 Antibody Induces Potent Tumor Regression with Reduced Off-Target Activity

Sarah L. Pogue; Tetsuya Taura; Mingying Bi; Yong Yun; Angela Sho; Glen Mikesell; Collette Behrens; Maya Sokolovsky; Hussein Hallak; Moti Rosenstock; Eric Sanchez; Haiming Chen; James Berenson; Anthony Doyle; Steffen Nock; David S. Wilson

doi:10.1371/journal.pone.0162472

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Open Access

Peer-reviewed

Research Article

Targeting Attenuated Interferon-α to Myeloma Cells with a CD38 Antibody Induces Potent Tumor Regression with Reduced Off-Target Activity

Sarah L. Pogue ,

* E-mail: Sarah.Pogue@tevapharm.com

Affiliation Teva Pharmaceuticals, Global Branded Biologics Division, Redwood City, California, United States of America
⨯
Tetsuya Taura,

Affiliation Teva Pharmaceuticals, Global Branded Biologics Division, Redwood City, California, United States of America
⨯
Mingying Bi,

Affiliation Teva Pharmaceuticals, Global Branded Biologics Division, Redwood City, California, United States of America
⨯
Yong Yun,

Affiliation Teva Pharmaceuticals, Global Branded Biologics Division, Redwood City, California, United States of America
⨯
Angela Sho,

Affiliation Teva Pharmaceuticals, Global Branded Biologics Division, Redwood City, California, United States of America
⨯
Glen Mikesell,

Affiliation Teva Pharmaceuticals, Global Branded Biologics Division, Redwood City, California, United States of America
⨯
Collette Behrens,

Affiliation Teva Pharmaceuticals, Global Branded Biologics Division, Sydney, Australia
⨯
Maya Sokolovsky,

Affiliation Teva Pharmaceuticals, Global Branded Biologics Division, Netanya, Israel
⨯
Hussein Hallak,

Affiliation Teva Pharmaceuticals, Global Branded Biologics Division, Netanya, Israel
⨯
Moti Rosenstock,

Affiliation Teva Pharmaceuticals, Global Branded Biologics Division, Netanya, Israel
⨯
Eric Sanchez,

Affiliation The Institute for Myeloma and Bone Cancer Research, West Hollywood, California, United States of America
⨯
Haiming Chen,

Affiliation The Institute for Myeloma and Bone Cancer Research, West Hollywood, California, United States of America
⨯
James Berenson,

Affiliation The Institute for Myeloma and Bone Cancer Research, West Hollywood, California, United States of America
⨯
Anthony Doyle,

Affiliation Teva Pharmaceuticals, Global Branded Biologics Division, Sydney, Australia
⨯
Steffen Nock,

Affiliation Teva Pharmaceuticals, Global Branded Biologics Division, Redwood City, California, United States of America
⨯
[ ... ],
David S. Wilson

Affiliation Teva Pharmaceuticals, Global Branded Biologics Division, Redwood City, California, United States of America
⨯
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Targeting Attenuated Interferon-α to Myeloma Cells with a CD38 Antibody Induces Potent Tumor Regression with Reduced Off-Target Activity

Sarah L. Pogue,
Tetsuya Taura,
Mingying Bi,
Yong Yun,
Angela Sho,
Glen Mikesell,
Collette Behrens,
Maya Sokolovsky,
Hussein Hallak,
Moti Rosenstock

Published: September 9, 2016
https://doi.org/10.1371/journal.pone.0162472

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