A Novel High-Throughput 3D Screening System for EMT Inhibitors: A Pilot Screening Discovered the EMT Inhibitory Activity of CDK2 Inhibitor SU9516

Kazuya Arai; Takanori Eguchi; M. Mamunur Rahman; Ruriko Sakamoto; Norio Masuda; Tetsuya Nakatsura; Stuart K. Calderwood; Ken-ichi Kozaki; Manabu Itoh

doi:10.1371/journal.pone.0162394

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Open Access

Peer-reviewed

Research Article

A Novel High-Throughput 3D Screening System for EMT Inhibitors: A Pilot Screening Discovered the EMT Inhibitory Activity of CDK2 Inhibitor SU9516

Kazuya Arai ,

* E-mail: kazuya_arai@organogenix.com (KA); eguchi@okayama-u.ac.jp (TE)

Current address: ORGANOGENIX, Inc. Kawasaki, Kanagawa, Japan

Affiliations SCIVAX Life Sciences, Inc., Kawasaki, Kanagawa, Japan, SCIVAX USA, Inc., Woburn, Massachusetts, United States of America

http://orcid.org/0000-0003-2420-4596

⨯
Takanori Eguchi ,

* E-mail: kazuya_arai@organogenix.com (KA); eguchi@okayama-u.ac.jp (TE)

Affiliations Department of Radiation Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Dental Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan, Advanced Research Center for Oral and Craniofacial Sciences, Okayama University Dental School / Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, 700–8525, Japan
⨯
M. Mamunur Rahman,

Affiliation SCIVAX USA, Inc., Woburn, Massachusetts, United States of America
⨯
Ruriko Sakamoto,

Affiliation SCIVAX Life Sciences, Inc., Kawasaki, Kanagawa, Japan
⨯
Norio Masuda,

Current address: ORGANOGENIX, Inc. Kawasaki, Kanagawa, Japan

Affiliation SCIVAX Life Sciences, Inc., Kawasaki, Kanagawa, Japan
⨯
Tetsuya Nakatsura,

Affiliation Division of Cancer Immunotherapy, Exploratory Oncology Research & Clinical Trial Center, National Cancer Center, Kashiwa, Chiba, Japan
⨯
Stuart K. Calderwood,

Affiliation Department of Radiation Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Ken-ichi Kozaki,

Affiliation Department of Dental Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
⨯
Manabu Itoh

Current address: ORGANOGENIX, Inc. Kawasaki, Kanagawa, Japan

Affiliation SCIVAX Life Sciences, Inc., Kawasaki, Kanagawa, Japan
⨯

A Novel High-Throughput 3D Screening System for EMT Inhibitors: A Pilot Screening Discovered the EMT Inhibitory Activity of CDK2 Inhibitor SU9516

Kazuya Arai,
Takanori Eguchi,
M. Mamunur Rahman,
Ruriko Sakamoto,
Norio Masuda,
Tetsuya Nakatsura,
Stuart K. Calderwood,
Ken-ichi Kozaki,
Manabu Itoh

Published: September 13, 2016
https://doi.org/10.1371/journal.pone.0162394

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