Progression of Behavioral and CNS Deficits in a Viable Murine Model of Chronic Neuronopathic Gaucher Disease

Mei Dai; Benjamin Liou; Brittany Swope; Xiaohong Wang; Wujuan Zhang; Venette Inskeep; Gregory A. Grabowski; Ying Sun; Dao Pan

doi:10.1371/journal.pone.0162367

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Peer-reviewed

Research Article

Progression of Behavioral and CNS Deficits in a Viable Murine Model of Chronic Neuronopathic Gaucher Disease

Mei Dai,

Affiliation Experimental Hematology and Cancer Biology, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, United States of America
⨯
Benjamin Liou,

Affiliation Division of Human Genetics, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, United States of America
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Brittany Swope,

Affiliations Experimental Hematology and Cancer Biology, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, United States of America, Department of Pediatrics, University of Cincinnati School of Medicine, Cincinnati, Ohio, United States of America
⨯
Xiaohong Wang,

Affiliation Experimental Hematology and Cancer Biology, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, United States of America
⨯
Wujuan Zhang,

Affiliation Division of Pathology, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, United States of America
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Venette Inskeep,

Affiliation Division of Human Genetics, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, United States of America
⨯
Gregory A. Grabowski,

Affiliation Division of Human Genetics, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, United States of America
⨯
Ying Sun ,

* E-mail: Dao.pan@cchmc.org (DP); ying.sun@cchmc.org (YS)

Affiliations Division of Human Genetics, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, United States of America, Department of Pediatrics, University of Cincinnati School of Medicine, Cincinnati, Ohio, United States of America
⨯
Dao Pan

* E-mail: Dao.pan@cchmc.org (DP); ying.sun@cchmc.org (YS)

Affiliations Experimental Hematology and Cancer Biology, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, United States of America, Department of Pediatrics, University of Cincinnati School of Medicine, Cincinnati, Ohio, United States of America
⨯

Progression of Behavioral and CNS Deficits in a Viable Murine Model of Chronic Neuronopathic Gaucher Disease

Mei Dai,
Benjamin Liou,
Brittany Swope,
Xiaohong Wang,
Wujuan Zhang,
Venette Inskeep,
Gregory A. Grabowski,
Ying Sun,
Dao Pan

Published: September 6, 2016
https://doi.org/10.1371/journal.pone.0162367

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