Driving the Model to Its Limit: Profile Likelihood Based Model Reduction

• Tim Maiwald ,

  Contributed equally to this work with: Tim Maiwald, Helge Hass, Bernhard Steiert

  Affiliation Institute of Physics, University of Freiburg, Freiburg im Breisgau, Germany

  http://orcid.org/0000-0002-4525-9556

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• Helge Hass ,

  Contributed equally to this work with: Tim Maiwald, Helge Hass, Bernhard Steiert

  Affiliation Institute of Physics, University of Freiburg, Freiburg im Breisgau, Germany

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• Bernhard Steiert ,

  Contributed equally to this work with: Tim Maiwald, Helge Hass, Bernhard Steiert

  Affiliation Institute of Physics, University of Freiburg, Freiburg im Breisgau, Germany

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• Joep Vanlier,

  Affiliation Institute of Physics, University of Freiburg, Freiburg im Breisgau, Germany

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• Raphael Engesser,

  Affiliation Institute of Physics, University of Freiburg, Freiburg im Breisgau, Germany

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• Andreas Raue,

  Affiliation Merrimack Pharmaceuticals, Boston, MA, United States of America

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• Friederike Kipkeew,

  Affiliation Department of Gastroenterology, Hepatology and Infectiology, University Hospital Duesseldorf, Duesseldorf, Germany

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• Hans H. Bock,

  Affiliation Department of Gastroenterology, Hepatology and Infectiology, University Hospital Duesseldorf, Duesseldorf, Germany

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• Daniel Kaschek,

  Affiliation Institute of Physics, University of Freiburg, Freiburg im Breisgau, Germany

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• Clemens Kreutz,

  Affiliations Institute of Physics, University of Freiburg, Freiburg im Breisgau, Germany, Center for Biosystems Analysis (ZBSA), University of Freiburg, Freiburg im Breisgau, Germany

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• Jens Timmer

  * E-mail: jeti@fdm.uni-freiburg.de

  Affiliations Institute of Physics, University of Freiburg, Freiburg im Breisgau, Germany, Center for Biosystems Analysis (ZBSA), University of Freiburg, Freiburg im Breisgau, Germany, BIOSS Centre for Biological Signalling Studies, University of Freiburg, Freiburg im Breisgau, Germany

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