Single Nucleotide Polymorphisms at +191 and +292 of Galectin-3 Gene (LGALS3) Related to Lower GAL-3 Serum Levels Are Associated with Frequent Respiratory Tract Infection and Vaso-Occlusive Crisis in Children with Sickle Cell Anemia

Taciana Furtado de Mendonça Belmont; Kleyton Palmeira do Ó; Andreia Soares da Silva; Kamila de Melo Vilar; Fernanda Silva Medeiros; Luydson Richardson Silva Vasconcelos; Ana Claudia Mendonça dos Anjos; Betânia Lucena Domingues Hatzlhofer; Maíra Galdino da Rocha Pitta; Marcos André Cavalcanti Bezerra; Aderson da Silva Araújo; Moacyr Jesus Barreto de Melo Rego; Patrícia Moura; Maria do Socorro Mendonça Cavalcanti

doi:10.1371/journal.pone.0162297

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Peer-reviewed

Research Article

Single Nucleotide Polymorphisms at +191 and +292 of Galectin-3 Gene (LGALS3) Related to Lower GAL-3 Serum Levels Are Associated with Frequent Respiratory Tract Infection and Vaso-Occlusive Crisis in Children with Sickle Cell Anemia

Taciana Furtado de Mendonça Belmont,

Affiliation Programa de Doutorado da Rede Nordeste de Biotecnologia, Recife, Brasil
⨯
Kleyton Palmeira do Ó,

Affiliation Instituto de Ciências Biológicas e Faculdade de Ciências Médicas, Universidade de Pernambuco, Recife, Brasil
⨯
Andreia Soares da Silva,

Affiliation Instituto de Ciências Biológicas e Faculdade de Ciências Médicas, Universidade de Pernambuco, Recife, Brasil
⨯
Kamila de Melo Vilar,

Affiliation Laboratório de Imunomodulação e Novas Abordagens Terapêutica (LINAT), Universidade Federal de Pernambuco, Recife, Brasil
⨯
Fernanda Silva Medeiros,

Affiliation Instituto de Ciências Biológicas e Faculdade de Ciências Médicas, Universidade de Pernambuco, Recife, Brasil
⨯
Luydson Richardson Silva Vasconcelos,

Affiliation Centro de Pesquisas Aggeu Magalhães, CPqAM-FIOCRUZ-PE, Recife, State of Pernambuco, Brazil
⨯
Ana Claudia Mendonça dos Anjos,

Affiliation Fundação Hematologia e Hemoterapia de Pernambuco (HEMOPE), Recife, Brasil
⨯
Betânia Lucena Domingues Hatzlhofer,

Affiliation Departamento de Ciências Biológicas, Universidade Federal de Pernambuco, Recife, Brasil
⨯
Maíra Galdino da Rocha Pitta,

Affiliation Laboratório de Imunomodulação e Novas Abordagens Terapêutica (LINAT), Universidade Federal de Pernambuco, Recife, Brasil
⨯
Marcos André Cavalcanti Bezerra,

Affiliation Departamento de Ciências Biológicas, Universidade Federal de Pernambuco, Recife, Brasil
⨯
Aderson da Silva Araújo,

Affiliation Fundação Hematologia e Hemoterapia de Pernambuco (HEMOPE), Recife, Brasil
⨯
Moacyr Jesus Barreto de Melo Rego,

Affiliation Laboratório de Imunomodulação e Novas Abordagens Terapêutica (LINAT), Universidade Federal de Pernambuco, Recife, Brasil
⨯
Patrícia Moura ,

* E-mail: patricia.moura@upe.br

Affiliations Programa de Doutorado da Rede Nordeste de Biotecnologia, Recife, Brasil, Instituto de Ciências Biológicas e Faculdade de Ciências Médicas, Universidade de Pernambuco, Recife, Brasil
⨯
Maria do Socorro Mendonça Cavalcanti

Affiliations Programa de Doutorado da Rede Nordeste de Biotecnologia, Recife, Brasil, Instituto de Ciências Biológicas e Faculdade de Ciências Médicas, Universidade de Pernambuco, Recife, Brasil
⨯

Single Nucleotide Polymorphisms at +191 and +292 of Galectin-3 Gene (LGALS3) Related to Lower GAL-3 Serum Levels Are Associated with Frequent Respiratory Tract Infection and Vaso-Occlusive Crisis in Children with Sickle Cell Anemia

Taciana Furtado de Mendonça Belmont,
Kleyton Palmeira do Ó,
Andreia Soares da Silva,
Kamila de Melo Vilar,
Fernanda Silva Medeiros,
Luydson Richardson Silva Vasconcelos,
Ana Claudia Mendonça dos Anjos,
Betânia Lucena Domingues Hatzlhofer,
Maíra Galdino da Rocha Pitta,
Marcos André Cavalcanti Bezerra

Published: September 7, 2016
https://doi.org/10.1371/journal.pone.0162297

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