Mogrol Derived from Siraitia grosvenorii Mogrosides Suppresses 3T3-L1 Adipocyte Differentiation by Reducing cAMP-Response Element-Binding Protein Phosphorylation and Increasing AMP-Activated Protein Kinase Phosphorylation

Naoki Harada; Mikako Ishihara; Hiroko Horiuchi; Yuta Ito; Hiromitsu Tabata; Yasushi A. Suzuki; Yoshihisa Nakano; Ryoichi Yamaji; Hiroshi Inui

doi:10.1371/journal.pone.0162252

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Research Article

Mogrol Derived from Siraitia grosvenorii Mogrosides Suppresses 3T3-L1 Adipocyte Differentiation by Reducing cAMP-Response Element-Binding Protein Phosphorylation and Increasing AMP-Activated Protein Kinase Phosphorylation

Naoki Harada ,

* E-mail: harada@biochem.osakafu-u.ac.jp (NH); inui@biochem.osakafu-u.ac.jp (HI)

Affiliation Division of Applied Life Sciences, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Sakai, Osaka, Japan
⨯
Mikako Ishihara,

Affiliation Division of Applied Life Sciences, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Sakai, Osaka, Japan
⨯
Hiroko Horiuchi,

Affiliation Division of Applied Life Sciences, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Sakai, Osaka, Japan
⨯
Yuta Ito,

Affiliations Division of Applied Life Sciences, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Sakai, Osaka, Japan, Biochemical Laboratory, Saraya Company, Ltd., Kashiwara, Osaka, Japan
⨯
Hiromitsu Tabata,

Affiliation Biochemical Laboratory, Saraya Company, Ltd., Kashiwara, Osaka, Japan
⨯
Yasushi A. Suzuki,

Affiliation Biochemical Laboratory, Saraya Company, Ltd., Kashiwara, Osaka, Japan
⨯
Yoshihisa Nakano,

Affiliation Center for Research and Development of Bioresources, Osaka Prefecture University, Sakai, Osaka, Japan
⨯
Ryoichi Yamaji,

Affiliation Division of Applied Life Sciences, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Sakai, Osaka, Japan
⨯
Hiroshi Inui

* E-mail: harada@biochem.osakafu-u.ac.jp (NH); inui@biochem.osakafu-u.ac.jp (HI)

Affiliations Center for Research and Development of Bioresources, Osaka Prefecture University, Sakai, Osaka, Japan, Department of Nutrition, Osaka Prefecture University, Habikino, Osaka, Japan
⨯

Mogrol Derived from Siraitia grosvenorii Mogrosides Suppresses 3T3-L1 Adipocyte Differentiation by Reducing cAMP-Response Element-Binding Protein Phosphorylation and Increasing AMP-Activated Protein Kinase Phosphorylation

Naoki Harada,
Mikako Ishihara,
Hiroko Horiuchi,
Yuta Ito,
Hiromitsu Tabata,
Yasushi A. Suzuki,
Yoshihisa Nakano,
Ryoichi Yamaji,
Hiroshi Inui

Published: September 1, 2016
https://doi.org/10.1371/journal.pone.0162252

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Cell differentiation
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Adipocyte differentiation
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Phosphorylation
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Lipids
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CREB signaling
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Insulin
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