Preclinical Metabolism, Pharmacokinetics and In Vivo Analysis of New Blood-Brain-Barrier Penetrant Fingolimod Analogues: FTY720-C2 and FTY720-Mitoxy

Julius O. Enoru; Barbara Yang; Sesha Krishnamachari; Ernesto Villanueva; William DeMaio; Adiba Watanyar; Ramesh Chinnasamy; Jeffrey B. Arterburn; Ruth G. Perez

doi:10.1371/journal.pone.0162162

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Peer-reviewed

Research Article

Preclinical Metabolism, Pharmacokinetics and In Vivo Analysis of New Blood-Brain-Barrier Penetrant Fingolimod Analogues: FTY720-C2 and FTY720-Mitoxy

Julius O. Enoru ,

Contributed equally to this work with: Julius O. Enoru, Barbara Yang, Sesha Krishnamachari

Affiliation In Vitro and Molecular Metabolism Laboratory, Ricerca Biosciences LLC, Concord, Ohio, United States of America
⨯
Barbara Yang ,

Contributed equally to this work with: Julius O. Enoru, Barbara Yang, Sesha Krishnamachari

Affiliation Department of Biomedical Sciences, Graduate School of Biomedical Sciences, Center of Emphasis in Neurosciences, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center El Paso, El Paso, Texas, United States of America
⨯
Sesha Krishnamachari ,

Contributed equally to this work with: Julius O. Enoru, Barbara Yang, Sesha Krishnamachari

Affiliation Department of Biomedical Sciences, Graduate School of Biomedical Sciences, Center of Emphasis in Neurosciences, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center El Paso, El Paso, Texas, United States of America
⨯
Ernesto Villanueva,

Affiliation Department of Biomedical Sciences, Graduate School of Biomedical Sciences, Center of Emphasis in Neurosciences, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center El Paso, El Paso, Texas, United States of America
⨯
William DeMaio,

Affiliation In Vitro and Molecular Metabolism Laboratory, Ricerca Biosciences LLC, Concord, Ohio, United States of America
⨯
Adiba Watanyar,

Affiliation In Vitro and Molecular Metabolism Laboratory, Ricerca Biosciences LLC, Concord, Ohio, United States of America
⨯
Ramesh Chinnasamy,

Affiliation Department of Chemistry and Biochemistry, New Mexico State University, Las Cruces, New Mexico, United States of America
⨯
Jeffrey B. Arterburn,

Affiliation Department of Chemistry and Biochemistry, New Mexico State University, Las Cruces, New Mexico, United States of America
⨯
Ruth G. Perez

* E-mail: ruth.g.perez@ttuhsc.edu

Affiliation Department of Biomedical Sciences, Graduate School of Biomedical Sciences, Center of Emphasis in Neurosciences, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center El Paso, El Paso, Texas, United States of America
⨯

Preclinical Metabolism, Pharmacokinetics and In Vivo Analysis of New Blood-Brain-Barrier Penetrant Fingolimod Analogues: FTY720-C2 and FTY720-Mitoxy

Julius O. Enoru,
Barbara Yang,
Sesha Krishnamachari,
Ernesto Villanueva,
William DeMaio,
Adiba Watanyar,
Ramesh Chinnasamy,
Jeffrey B. Arterburn,
Ruth G. Perez

Published: September 9, 2016
https://doi.org/10.1371/journal.pone.0162162

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