A Qualitative Model of the Differentiation Network in Chondrocyte Maturation: A Holistic View of Chondrocyte Hypertrophy

Open Access

Peer-reviewed

Research Article

Johan Kerkhofs,

Affiliations Biomechanics Research Unit, University of Liège, Liège, Belgium, Biomechanics section, KU Leuven, Leuven, Belgium, Prometheus, the Leuven R&D division of skeletal tissue engineering, KU Leuven, Leuven, Belgium
⨯
Jeroen Leijten,

Affiliations Prometheus, the Leuven R&D division of skeletal tissue engineering, KU Leuven, Leuven, Belgium, Skeletal Biology and Engineering Research Center, KU Leuven, Leuven, Belgium
⨯
Johanna Bolander,

Affiliations Prometheus, the Leuven R&D division of skeletal tissue engineering, KU Leuven, Leuven, Belgium, Skeletal Biology and Engineering Research Center, KU Leuven, Leuven, Belgium
⨯
Frank P. Luyten,

Affiliations Prometheus, the Leuven R&D division of skeletal tissue engineering, KU Leuven, Leuven, Belgium, Skeletal Biology and Engineering Research Center, KU Leuven, Leuven, Belgium
⨯
Janine N. Post,

Affiliation Developmental BioEngineering, MIRA Institute for biomedical technology and technical medicine, University of Twente, Enschede, The Netherlands
⨯
Liesbet Geris

* E-mail: liesbet.geris@ulg.ac.be

Affiliations Biomechanics Research Unit, University of Liège, Liège, Belgium, Biomechanics section, KU Leuven, Leuven, Belgium, Prometheus, the Leuven R&D division of skeletal tissue engineering, KU Leuven, Leuven, Belgium
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Chondrocytes
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Osteoarthritis
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Cartilage
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Transcription factors
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Growth factors
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BMP signaling
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Growth plate
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Network analysis
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