Tyrosinase-Cre-Mediated Deletion of the Autophagy Gene Atg7 Leads to Accumulation of the RPE65 Variant M450 in the Retinal Pigment Epithelium of C57BL/6 Mice

Supawadee Sukseree; Ying-Ting Chen; Maria Laggner; Florian Gruber; Valérie Petit; Ionela-Mariana Nagelreiter; Veronika Mlitz; Heidemarie Rossiter; Andreas Pollreisz; Ursula Schmidt-Erfurth; Lionel Larue; Erwin Tschachler; Leopold Eckhart

doi:10.1371/journal.pone.0161640

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Peer-reviewed

Research Article

Tyrosinase-Cre-Mediated Deletion of the Autophagy Gene Atg7 Leads to Accumulation of the RPE65 Variant M450 in the Retinal Pigment Epithelium of C57BL/6 Mice

Supawadee Sukseree,

Affiliation Research Division of Biology and Pathobiology of the Skin, Department of Dermatology, Medical University of Vienna, Vienna, Austria
⨯
Ying-Ting Chen,

Affiliation Department of Ophthalmology, Medical University of Vienna, Vienna, Austria
⨯
Maria Laggner,

Affiliation Department of Ophthalmology, Medical University of Vienna, Vienna, Austria
⨯
Florian Gruber,

Affiliations Research Division of Biology and Pathobiology of the Skin, Department of Dermatology, Medical University of Vienna, Vienna, Austria, Christian Doppler Laboratory for Biotechnology of Skin Aging, Vienna, Austria
⨯
Valérie Petit,

Affiliations Institut Curie, PSL Research University, INSERM U1021, CNRS UMR3347, Normal and Pathological Development of Melanocytes, Orsay, France, INSERM, Orsay, France, Equipe labellisée – Ligue Nationale contre le Cancer, Université Paris 11, Orsay, France
⨯
Ionela-Mariana Nagelreiter,

Affiliations Research Division of Biology and Pathobiology of the Skin, Department of Dermatology, Medical University of Vienna, Vienna, Austria, Christian Doppler Laboratory for Biotechnology of Skin Aging, Vienna, Austria
⨯
Veronika Mlitz,

Affiliation Research Division of Biology and Pathobiology of the Skin, Department of Dermatology, Medical University of Vienna, Vienna, Austria
⨯
Heidemarie Rossiter,

Affiliation Research Division of Biology and Pathobiology of the Skin, Department of Dermatology, Medical University of Vienna, Vienna, Austria
⨯
Andreas Pollreisz,

Affiliation Department of Ophthalmology, Medical University of Vienna, Vienna, Austria
⨯
Ursula Schmidt-Erfurth,

Affiliation Department of Ophthalmology, Medical University of Vienna, Vienna, Austria
⨯
Lionel Larue,

Affiliations Institut Curie, PSL Research University, INSERM U1021, CNRS UMR3347, Normal and Pathological Development of Melanocytes, Orsay, France, INSERM, Orsay, France, Equipe labellisée – Ligue Nationale contre le Cancer, Université Paris 11, Orsay, France
⨯
Erwin Tschachler,

Affiliation Research Division of Biology and Pathobiology of the Skin, Department of Dermatology, Medical University of Vienna, Vienna, Austria
⨯
Leopold Eckhart

* E-mail: leopold.eckhart@meduniwien.ac.at

Affiliation Research Division of Biology and Pathobiology of the Skin, Department of Dermatology, Medical University of Vienna, Vienna, Austria

http://orcid.org/0000-0002-5645-2036

⨯

Tyrosinase-Cre-Mediated Deletion of the Autophagy Gene Atg7 Leads to Accumulation of the RPE65 Variant M450 in the Retinal Pigment Epithelium of C57BL/6 Mice

Supawadee Sukseree,
Ying-Ting Chen,
Maria Laggner,
Florian Gruber,
Valérie Petit,
Ionela-Mariana Nagelreiter,
Veronika Mlitz,
Heidemarie Rossiter,
Andreas Pollreisz,
Ursula Schmidt-Erfurth

Published: August 18, 2016
https://doi.org/10.1371/journal.pone.0161640

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