Imaging Mass Spectrometry Revealed the Accumulation Characteristics of the 2-Nitroimidazole-Based Agent “Pimonidazole” in Hypoxia

• Yukiko Masaki ,

  Contributed equally to this work with: Yukiko Masaki, Yoichi Shimizu

  Affiliation Shionogi Innovation Center for Drug Discovery, Discovery Research Laboratory for Innovative Frontier Medicines, Shionogi & Co., Ltd., Sapporo, Japan

  ⨯
• Yoichi Shimizu ,

  Contributed equally to this work with: Yukiko Masaki, Yoichi Shimizu

  * E-mail: yshimizu@pharm.hokudai.ac.jp

  Affiliations Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan, Central Institute of Isotope Science, Hokkaido University, Sapporo, Japan

  ⨯
• Takeshi Yoshioka,

  Affiliation Shionogi Innovation Center for Drug Discovery, Discovery Research Laboratory for Innovative Frontier Medicines, Shionogi & Co., Ltd., Sapporo, Japan

  ⨯
• Fei Feng,

  Affiliation Graduate School of Medicine, Hokkaido University, Sapporo, Japan

  ⨯
• Songji Zhao,

  Affiliation Graduate School of Medicine, Hokkaido University, Sapporo, Japan

  ⨯
• Kenichi Higashino,

  Affiliation Shionogi Innovation Center for Drug Discovery, Discovery Research Laboratory for Innovative Frontier Medicines, Shionogi & Co., Ltd., Sapporo, Japan

  ⨯
• Yoshito Numata,

  Affiliation Shionogi Innovation Center for Drug Discovery, Discovery Research Laboratory for Innovative Frontier Medicines, Shionogi & Co., Ltd., Sapporo, Japan

  ⨯
• Yuji Kuge

  Affiliations Central Institute of Isotope Science, Hokkaido University, Sapporo, Japan, Graduate School of Medicine, Hokkaido University, Sapporo, Japan

  ⨯