Interstitial Perfusion Culture with Specific Soluble Factors Inhibits Type I Collagen Production from Human Osteoarthritic Chondrocytes in Clinical-Grade Collagen Sponges

• Nathalie Mayer ,

  Contributed equally to this work with: Nathalie Mayer, Silvia Lopa

  Affiliation Laboratory of Tissue Biology and Therapeutic Engineering, CNRS UMR 5305, Université Claude Bernard-Lyon 1 and University of Lyon, Institute for Biology and Chemistry of Proteins, Lyon, France

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• Silvia Lopa ,

  Contributed equally to this work with: Nathalie Mayer, Silvia Lopa

  Affiliation Cell and Tissue Engineering Laboratory, IRCCS Galeazzi Orthopaedic Institute, Milan, Italy

  http://orcid.org/0000-0003-0410-5814

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• Giuseppe Talò,

  Affiliation Cell and Tissue Engineering Laboratory, IRCCS Galeazzi Orthopaedic Institute, Milan, Italy

  ⨯
• Arianna B. Lovati,

  Affiliation Cell and Tissue Engineering Laboratory, IRCCS Galeazzi Orthopaedic Institute, Milan, Italy

  ⨯
• Marielle Pasdeloup,

  Affiliation Laboratory of Tissue Biology and Therapeutic Engineering, CNRS UMR 5305, Université Claude Bernard-Lyon 1 and University of Lyon, Institute for Biology and Chemistry of Proteins, Lyon, France

  ⨯
• Stefania A. Riboldi,

  Affiliation Bioengineering Laboratories S.r.l., Meda, Italy

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• Matteo Moretti ,

  ¶‡ These authors also contributed equally to this work.

  Affiliations Cell and Tissue Engineering Laboratory, IRCCS Galeazzi Orthopaedic Institute, Milan, Italy, Regenerative Medicine Technologies Lab, Ente Ospedaliero Cantonale (EOC), Lugano, Switzerland, Swiss Institute of Regenerative Medicine (SIRM), Lugano, Switzerland, Fondazione Cardiocentro Ticino, Lugano, Switzerland

  ⨯
• Frédéric Mallein-Gerin

  * E-mail: f.mallein-gerin@ibcp.fr

  ¶‡ These authors also contributed equally to this work.

  Affiliation Laboratory of Tissue Biology and Therapeutic Engineering, CNRS UMR 5305, Université Claude Bernard-Lyon 1 and University of Lyon, Institute for Biology and Chemistry of Proteins, Lyon, France

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