Analysis of Founder Mutations in Rare Tumors Associated With Hereditary Breast/Ovarian Cancer Reveals a Novel Association of BRCA2 Mutations with Ampulla of Vater Carcinomas

Pedro Pinto; Ana Peixoto; Catarina Santos; Patrícia Rocha; Carla Pinto; Manuela Pinheiro; Luís Leça; Ana Teresa Martins; Verónica Ferreira; Carla Bartosch; Manuel R. Teixeira

doi:10.1371/journal.pone.0161438

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Open Access

Peer-reviewed

Research Article

Analysis of Founder Mutations in Rare Tumors Associated With Hereditary Breast/Ovarian Cancer Reveals a Novel Association of BRCA2 Mutations with Ampulla of Vater Carcinomas

Pedro Pinto,

Affiliation Department of Genetics, Portuguese Oncology Institute of Porto (IPO-Porto), Porto, Portugal
⨯
Ana Peixoto,

Affiliation Department of Genetics, Portuguese Oncology Institute of Porto (IPO-Porto), Porto, Portugal
⨯
Catarina Santos,

Affiliation Department of Genetics, Portuguese Oncology Institute of Porto (IPO-Porto), Porto, Portugal
⨯
Patrícia Rocha,

Affiliation Department of Genetics, Portuguese Oncology Institute of Porto (IPO-Porto), Porto, Portugal
⨯
Carla Pinto,

Affiliation Department of Genetics, Portuguese Oncology Institute of Porto (IPO-Porto), Porto, Portugal
⨯
Manuela Pinheiro,

Affiliation Department of Genetics, Portuguese Oncology Institute of Porto (IPO-Porto), Porto, Portugal
⨯
Luís Leça,

Affiliation Department of Pathology, Portuguese Oncology Institute of Porto (IPO-Porto), Porto, Portugal
⨯
Ana Teresa Martins,

Affiliation Department of Pathology, Portuguese Oncology Institute of Porto (IPO-Porto), Porto, Portugal
⨯
Verónica Ferreira,

Affiliation Department of Pathology, Portuguese Oncology Institute of Porto (IPO-Porto), Porto, Portugal
⨯
Carla Bartosch,

Affiliation Department of Pathology, Portuguese Oncology Institute of Porto (IPO-Porto), Porto, Portugal
⨯
Manuel R. Teixeira

* E-mail: manuel.teixeira@ipoporto.min-saude.pt

Affiliations Department of Genetics, Portuguese Oncology Institute of Porto (IPO-Porto), Porto, Portugal, Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, Porto, Portugal

http://orcid.org/0000-0002-3633-1659

⨯

Analysis of Founder Mutations in Rare Tumors Associated With Hereditary Breast/Ovarian Cancer Reveals a Novel Association of BRCA2 Mutations with Ampulla of Vater Carcinomas

Pedro Pinto,
Ana Peixoto,
Catarina Santos,
Patrícia Rocha,
Carla Pinto,
Manuela Pinheiro,
Luís Leça,
Ana Teresa Martins,
Verónica Ferreira,
Carla Bartosch

Published: August 17, 2016
https://doi.org/10.1371/journal.pone.0161438

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