Vaccine-Mediated Activation of Human TLR4 Is Affected by Modulation of Culture Conditions during Whole-Cell Pertussis Vaccine Preparation

Open Access

Peer-reviewed

Research Article

Marieke E. Hoonakker ,

* E-mail: Marieke.Hoonakker@intravacc.nl

Affiliations Institute for Translational Vaccinology (Intravacc), Bilthoven, The Netherlands, Department of Animals in Science and Society, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands
⨯
Lisa M. Verhagen,

Affiliations Institute for Translational Vaccinology (Intravacc), Bilthoven, The Netherlands, Centre for Immunology of Infectious Diseases and Vaccines, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
⨯
Elder Pupo,

Affiliation Institute for Translational Vaccinology (Intravacc), Bilthoven, The Netherlands
⨯
Alex de Haan,

Affiliation Institute for Translational Vaccinology (Intravacc), Bilthoven, The Netherlands
⨯
Bernard Metz,

Affiliation Institute for Translational Vaccinology (Intravacc), Bilthoven, The Netherlands
⨯
Coenraad F. M. Hendriksen,

Affiliations Institute for Translational Vaccinology (Intravacc), Bilthoven, The Netherlands, Department of Animals in Science and Society, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands
⨯
Wanda G. H. Han,

Affiliation Centre for Immunology of Infectious Diseases and Vaccines, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
⨯
Arjen Sloots

Affiliation Institute for Translational Vaccinology (Intravacc), Bilthoven, The Netherlands
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Vaccines
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Bordetella pertussis
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Sulfates
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Enzyme-linked immunoassays
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Antibodies
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Antigen-presenting cells
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Immune receptor signaling
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Toll-like receptors
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