Chemical Screens Identify Drugs that Enhance or Mitigate Cellular Responses to Antibody-Toxin Fusion Proteins

• Antonella Antignani ,

  Contributed equally to this work with: Antonella Antignani, Lesley Mathews Griner

  Affiliation Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892–4264, United States of America

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• Lesley Mathews Griner ,

  Contributed equally to this work with: Antonella Antignani, Lesley Mathews Griner

  Affiliation Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland, 20850, United States of America

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• Rajarshi Guha,

  Affiliation Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland, 20850, United States of America

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• Nathan Simon,

  Affiliation Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892–4264, United States of America

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• Matteo Pasetto,

  Current address: Department of Pathology, University of Verona, Verona, Italy.

  Affiliation Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892–4264, United States of America

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• Jonathan Keller,

  Affiliation Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland, 20850, United States of America

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• Manjie Huang,

  Affiliation Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892–4264, United States of America

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• Evan Angelus,

  Affiliation Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892–4264, United States of America

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• Ira Pastan,

  Affiliation Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892–4264, United States of America

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• Marc Ferrer,

  Affiliation Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland, 20850, United States of America

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• David J. FitzGerald ,

  * E-mail: fitzgerd@helix.nih.gov (DF); craigt@mail.nih.gov (CJT)

  Affiliation Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892–4264, United States of America

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• Craig J. Thomas

  * E-mail: fitzgerd@helix.nih.gov (DF); craigt@mail.nih.gov (CJT)

  Affiliation Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland, 20850, United States of America

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