Mitochondrial Probe Methyltriphenylphosphonium (TPMP) Inhibits the Krebs Cycle Enzyme 2-Oxoglutarate Dehydrogenase

Moustafa Elkalaf; Petr Tůma; Martin Weiszenstein; Jan Polák; Jan Trnka

doi:10.1371/journal.pone.0161413

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Peer-reviewed

Research Article

Mitochondrial Probe Methyltriphenylphosphonium (TPMP) Inhibits the Krebs Cycle Enzyme 2-Oxoglutarate Dehydrogenase

Moustafa Elkalaf,

Affiliations Laboratory for Metabolism and Bioenergetics, Third Faculty of Medicine, Charles University, Prague, Czech Republic, Centre for Research on Diabetes, Metabolism and Nutrition, Third Faculty of Medicine, Charles University, Prague, Czech Republic
⨯
Petr Tůma,

Affiliations Department of Biochemistry, Cell and Molecular Biology, Third Faculty of Medicine, Charles University, Prague, Czech Republic, Centre for Research on Diabetes, Metabolism and Nutrition, Third Faculty of Medicine, Charles University, Prague, Czech Republic
⨯
Martin Weiszenstein,

Affiliations Department of Sport Medicine, Third Faculty of Medicine, Charles University, Prague, Czech Republic, Centre for Research on Diabetes, Metabolism and Nutrition, Third Faculty of Medicine, Charles University, Prague, Czech Republic
⨯
Jan Polák,

Affiliations Department of Sport Medicine, Third Faculty of Medicine, Charles University, Prague, Czech Republic, Centre for Research on Diabetes, Metabolism and Nutrition, Third Faculty of Medicine, Charles University, Prague, Czech Republic
⨯
Jan Trnka

* E-mail: jan.trnka@lf3.cuni.cz

Affiliations Laboratory for Metabolism and Bioenergetics, Third Faculty of Medicine, Charles University, Prague, Czech Republic, Department of Biochemistry, Cell and Molecular Biology, Third Faculty of Medicine, Charles University, Prague, Czech Republic, Centre for Research on Diabetes, Metabolism and Nutrition, Third Faculty of Medicine, Charles University, Prague, Czech Republic

http://orcid.org/0000-0002-1786-7562

⨯

Mitochondrial Probe Methyltriphenylphosphonium (TPMP) Inhibits the Krebs Cycle Enzyme 2-Oxoglutarate Dehydrogenase

Moustafa Elkalaf,
Petr Tůma,
Martin Weiszenstein,
Jan Polák,
Jan Trnka

Published: August 18, 2016
https://doi.org/10.1371/journal.pone.0161413

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Mitochondria
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Citric acid cycle
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Membrane potential
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Pyruvate
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Enzyme inhibitors
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Dehydrogenases
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Cell membranes
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Cell metabolism
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