Elevating CLIC4 in Multiple Cell Types Reveals a TGF-β Dependent Induction of a Dominant Negative Smad7 Splice Variant

Anjali Shukla; Yihan Yang; Sara Madanikia; Yan Ho; Mangmang Li; Vanesa Sanchez; Christophe Cataisson; Jing Huang; Stuart H. Yuspa

doi:10.1371/journal.pone.0161410

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Open Access

Peer-reviewed

Research Article

Elevating CLIC4 in Multiple Cell Types Reveals a TGF-β Dependent Induction of a Dominant Negative Smad7 Splice Variant

Anjali Shukla,

Affiliation Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America
⨯
Yihan Yang,

Affiliation Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America
⨯
Sara Madanikia,

Affiliation Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America
⨯
Yan Ho,

Affiliation Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America
⨯
Mangmang Li,

Affiliation Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America
⨯
Vanesa Sanchez,

Affiliation Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America
⨯
Christophe Cataisson,

Affiliation Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America
⨯
Jing Huang,

Affiliation Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America
⨯
Stuart H. Yuspa

* E-mail: yuspas@mail.nih.gov

Affiliation Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America
⨯

Elevating CLIC4 in Multiple Cell Types Reveals a TGF-β Dependent Induction of a Dominant Negative Smad7 Splice Variant

Anjali Shukla,
Yihan Yang,
Sara Madanikia,
Yan Ho,
Mangmang Li,
Vanesa Sanchez,
Christophe Cataisson,
Jing Huang,
Stuart H. Yuspa

Published: August 18, 2016
https://doi.org/10.1371/journal.pone.0161410

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SMAD signaling
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Keratinocytes
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Signal inhibition
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Malignant tumors
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Adenoviruses
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Polymerase chain reaction
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RNA sequencing
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