Cardiac β2-Adrenergic Receptor Phosphorylation at Ser355/356 Regulates Receptor Internalization and Functional Resensitization

Xiaofang Fan; Xuejiang Gu; Ru Zhao; Qingqing Zheng; Lan Li; Wenbing Yang; Lu Ding; Feng Xue; Junming Fan; Yongsheng Gong; Yongyu Wang

doi:10.1371/journal.pone.0161373

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Open Access

Peer-reviewed

Research Article

Cardiac β₂-Adrenergic Receptor Phosphorylation at Ser^355/356 Regulates Receptor Internalization and Functional Resensitization

Xiaofang Fan ,

Contributed equally to this work with: Xiaofang Fan, Xuejiang Gu

Affiliation Institute of Hypoxia Medicine, Wenzhou Medical University, Wenzhou, Zhejiang, P.R. China
⨯
Xuejiang Gu ,

Contributed equally to this work with: Xiaofang Fan, Xuejiang Gu

Affiliation Department of Endocrine and Metabolic Diseases, 1st Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, P.R. China
⨯
Ru Zhao,

Affiliation Institute of Hypoxia Medicine, Wenzhou Medical University, Wenzhou, Zhejiang, P.R. China
⨯
Qingqing Zheng,

Affiliation Institute of Hypoxia Medicine, Wenzhou Medical University, Wenzhou, Zhejiang, P.R. China
⨯
Lan Li,

Affiliation Department of Pathology, Shantou University Medical College, Shantou, Guangdong, P.R. China
⨯
Wenbing Yang,

Affiliation Department of Pathology, Shantou University Medical College, Shantou, Guangdong, P.R. China
⨯
Lu Ding,

Affiliation Institute of Hypoxia Medicine, Wenzhou Medical University, Wenzhou, Zhejiang, P.R. China
⨯
Feng Xue,

Affiliation Institute of Hypoxia Medicine, Wenzhou Medical University, Wenzhou, Zhejiang, P.R. China
⨯
Junming Fan,

Affiliation Institute of Hypoxia Medicine, Wenzhou Medical University, Wenzhou, Zhejiang, P.R. China
⨯
Yongsheng Gong ,

* E-mail: yywangut@163.com (YW); fxb@wmu.edu.cn (YG)

Affiliation Institute of Hypoxia Medicine, Wenzhou Medical University, Wenzhou, Zhejiang, P.R. China
⨯
Yongyu Wang

* E-mail: yywangut@163.com (YW); fxb@wmu.edu.cn (YG)

Affiliation Institute of Hypoxia Medicine, Wenzhou Medical University, Wenzhou, Zhejiang, P.R. China
⨯

Cardiac β₂-Adrenergic Receptor Phosphorylation at Ser^355/356 Regulates Receptor Internalization and Functional Resensitization

Xiaofang Fan,
Xuejiang Gu,
Ru Zhao,
Qingqing Zheng,
Lan Li,
Wenbing Yang,
Lu Ding,
Feng Xue,
Junming Fan,
Yongsheng Gong

Published: August 19, 2016
https://doi.org/10.1371/journal.pone.0161373

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