Structural Characterization of Fibrils from Recombinant Human Islet Amyloid Polypeptide by Solid-State NMR: The Central FGAILS Segment Is Part of the β-Sheet Core

Open Access

Peer-reviewed

Research Article

Franziska Weirich,

Affiliations Institute of Complex Systems, Structural Biochemistry (ICS-6), Research Centre Jülich, 52425, Jülich, Germany, Institute of Physical Biology, Heinrich-Heine-Universität Düsseldorf, 40225, Düsseldorf, Germany
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Lothar Gremer,

Affiliations Institute of Complex Systems, Structural Biochemistry (ICS-6), Research Centre Jülich, 52425, Jülich, Germany, Institute of Physical Biology, Heinrich-Heine-Universität Düsseldorf, 40225, Düsseldorf, Germany
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Ewa A. Mirecka,

Affiliation Institute of Physical Biology, Heinrich-Heine-Universität Düsseldorf, 40225, Düsseldorf, Germany
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Stephanie Schiefer,

Affiliation Institute of Physical Biology, Heinrich-Heine-Universität Düsseldorf, 40225, Düsseldorf, Germany
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Wolfgang Hoyer,

Affiliations Institute of Complex Systems, Structural Biochemistry (ICS-6), Research Centre Jülich, 52425, Jülich, Germany, Institute of Physical Biology, Heinrich-Heine-Universität Düsseldorf, 40225, Düsseldorf, Germany
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Henrike Heise

* E-mail: h.heise@fz-juelich.de

Affiliations Institute of Complex Systems, Structural Biochemistry (ICS-6), Research Centre Jülich, 52425, Jülich, Germany, Institute of Physical Biology, Heinrich-Heine-Universität Düsseldorf, 40225, Düsseldorf, Germany
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Amyloid proteins
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Monomers
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Atomic force microscopy
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Dihedral angles
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Molecular structure
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Reversed-phase high performance liquid chromatography
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Protons
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Solid-state NMR spectroscopy
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