Volatile Organic Compound Gamma-Butyrolactone Released upon Herpes Simplex Virus Type -1 Acute Infection Modulated Membrane Potential and Repressed Viral Infection in Human Neuron-Like Cells

Kevin Rochford; Feng Chen; Yan Waguespack; Robert W. Figliozzi; Madan K. Kharel; Qiaojuan Zhang; Miguel Martin-Caraballo; S. Victor Hsia

doi:10.1371/journal.pone.0161119

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Research Article

Volatile Organic Compound Gamma-Butyrolactone Released upon Herpes Simplex Virus Type -1 Acute Infection Modulated Membrane Potential and Repressed Viral Infection in Human Neuron-Like Cells

Kevin Rochford ,

Contributed equally to this work with: Kevin Rochford, Feng Chen

Affiliations Department of Pharmaceutical Sciences, School of Pharmacy and Health Professions, University of Maryland, Eastern Shore, Princess Anne, Maryland, 21853, United States of America, Department of Natural Sciences, School of Agricultural and Natural Sciences, University of Maryland, Eastern Shore, Princess Anne, Maryland, 21853, United States of America
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Feng Chen ,

Contributed equally to this work with: Kevin Rochford, Feng Chen

Affiliation Department of Pharmaceutical Sciences, School of Pharmacy and Health Professions, University of Maryland, Eastern Shore, Princess Anne, Maryland, 21853, United States of America
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Yan Waguespack,

Affiliation Department of Natural Sciences, School of Agricultural and Natural Sciences, University of Maryland, Eastern Shore, Princess Anne, Maryland, 21853, United States of America
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Robert W. Figliozzi,

Affiliations Department of Pharmaceutical Sciences, School of Pharmacy and Health Professions, University of Maryland, Eastern Shore, Princess Anne, Maryland, 21853, United States of America, Department of Natural Sciences, School of Agricultural and Natural Sciences, University of Maryland, Eastern Shore, Princess Anne, Maryland, 21853, United States of America
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Madan K. Kharel,

Affiliation Department of Pharmaceutical Sciences, School of Pharmacy and Health Professions, University of Maryland, Eastern Shore, Princess Anne, Maryland, 21853, United States of America
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Qiaojuan Zhang,

Affiliation Department of Pharmaceutical Sciences, School of Pharmacy and Health Professions, University of Maryland, Eastern Shore, Princess Anne, Maryland, 21853, United States of America
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Miguel Martin-Caraballo,

Affiliation Department of Pharmaceutical Sciences, School of Pharmacy and Health Professions, University of Maryland, Eastern Shore, Princess Anne, Maryland, 21853, United States of America
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S. Victor Hsia

* E-mail: vhsia@umes.edu

Affiliation Department of Pharmaceutical Sciences, School of Pharmacy and Health Professions, University of Maryland, Eastern Shore, Princess Anne, Maryland, 21853, United States of America

http://orcid.org/0000-0001-7623-2842

⨯

Volatile Organic Compound Gamma-Butyrolactone Released upon Herpes Simplex Virus Type -1 Acute Infection Modulated Membrane Potential and Repressed Viral Infection in Human Neuron-Like Cells

Kevin Rochford,
Feng Chen,
Yan Waguespack,
Robert W. Figliozzi,
Madan K. Kharel,
Qiaojuan Zhang,
Miguel Martin-Caraballo,
S. Victor Hsia

Published: August 18, 2016
https://doi.org/10.1371/journal.pone.0161119

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