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Open Access

Peer-reviewed

Research Article

Differential Antitumoral Properties and Renal-Associated Tissue Damage Induced by Tacrolimus and Mammalian Target of Rapamycin Inhibitors in Hepatocarcinoma: In Vitro and In Vivo Studies

Elena Navarro-Villarán ,

Contributed equally to this work with: Elena Navarro-Villarán, José Tinoco, Granada Jiménez

Affiliation Institute of Biomedicine of Seville (IBIS), “Virgen del Rocío”-“Virgen Macarena” University Hospital/CSIC/University of Seville, Seville, Spain
⨯
José Tinoco ,

Contributed equally to this work with: Elena Navarro-Villarán, José Tinoco, Granada Jiménez

Affiliation Department of General Surgery, “Virgen del Rocío”-“Virgen Macarena” University Hospital/CSIC/University of Seville/IBIS/CSIC/University of Seville, Seville, Spain
⨯
Granada Jiménez ,

Contributed equally to this work with: Elena Navarro-Villarán, José Tinoco, Granada Jiménez

Affiliation Department of General Surgery, “Virgen del Rocío”-“Virgen Macarena” University Hospital/CSIC/University of Seville/IBIS/CSIC/University of Seville, Seville, Spain
⨯
Sheila Pereira,

Affiliation Institute of Biomedicine of Seville (IBIS), “Virgen del Rocío”-“Virgen Macarena” University Hospital/CSIC/University of Seville, Seville, Spain
⨯
Jize Wang,

Affiliation Department of General Surgery, “Virgen del Rocío”-“Virgen Macarena” University Hospital/CSIC/University of Seville/IBIS/CSIC/University of Seville, Seville, Spain
⨯
Sara Aliseda,

Affiliation Institute of Biomedicine of Seville (IBIS), “Virgen del Rocío”-“Virgen Macarena” University Hospital/CSIC/University of Seville, Seville, Spain
⨯
María A. Rodríguez-Hernández,

Affiliation Institute of Biomedicine of Seville (IBIS), “Virgen del Rocío”-“Virgen Macarena” University Hospital/CSIC/University of Seville, Seville, Spain
⨯
Raúl González,

Affiliation Institute of Biomedicine of Seville (IBIS), “Virgen del Rocío”-“Virgen Macarena” University Hospital/CSIC/University of Seville, Seville, Spain
⨯
Luís M. Marín-Gómez,

Affiliation Department of General Surgery, “Virgen del Rocío”-“Virgen Macarena” University Hospital/CSIC/University of Seville/IBIS/CSIC/University of Seville, Seville, Spain
⨯
Miguel A. Gómez-Bravo,

Affiliations Department of General Surgery, “Virgen del Rocío”-“Virgen Macarena” University Hospital/CSIC/University of Seville/IBIS/CSIC/University of Seville, Seville, Spain, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Madrid, Spain
⨯
Francisco J. Padillo,

Affiliations Department of General Surgery, “Virgen del Rocío”-“Virgen Macarena” University Hospital/CSIC/University of Seville/IBIS/CSIC/University of Seville, Seville, Spain, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Madrid, Spain
⨯
José M. Álamo-Martínez,

Affiliations Department of General Surgery, “Virgen del Rocío”-“Virgen Macarena” University Hospital/CSIC/University of Seville/IBIS/CSIC/University of Seville, Seville, Spain, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Madrid, Spain
⨯
Jordi Muntané

* E-mail: jmuntane-ibis@us.es

Affiliations Department of General Surgery, “Virgen del Rocío”-“Virgen Macarena” University Hospital/CSIC/University of Seville/IBIS/CSIC/University of Seville, Seville, Spain, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Madrid, Spain
⨯

Differential Antitumoral Properties and Renal-Associated Tissue Damage Induced by Tacrolimus and Mammalian Target of Rapamycin Inhibitors in Hepatocarcinoma: In Vitro and In Vivo Studies

Elena Navarro-Villarán,
José Tinoco,
Granada Jiménez,
Sheila Pereira,
Jize Wang,
Sara Aliseda,
María A. Rodríguez-Hernández,
Raúl González,
Luís M. Marín-Gómez,
Miguel A. Gómez-Bravo

x

Published: August 12, 2016
https://doi.org/10.1371/journal.pone.0160979

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Cell proliferation
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Hepatocellular carcinoma
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