Modification of Pulsed Electric Field Conditions Results in Distinct Activation Profiles of Platelet-Rich Plasma

Andrew L. Frelinger III; Anja J. Gerrits; Allen L. Garner; Andrew S. Torres; Antonio Caiafa; Christine A. Morton; Michelle A. Berny-Lang; Sabrina L. Carmichael; V. Bogdan Neculaes; Alan D. Michelson

doi:10.1371/journal.pone.0160933

Loading metrics

Open Access

Peer-reviewed

Research Article

Modification of Pulsed Electric Field Conditions Results in Distinct Activation Profiles of Platelet-Rich Plasma

Andrew L. Frelinger III ,

* E-mail: Andrew.Frelinger@childrens.harvard.edu (ALF); Neculaes@research.ge.com (VBN)

Affiliation Center for Platelet Research Studies, Division of Hematology/Oncology, Boston Children's Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Anja J. Gerrits,

Affiliation Center for Platelet Research Studies, Division of Hematology/Oncology, Boston Children's Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Allen L. Garner,

Affiliation School of Nuclear Engineering, Purdue University, West Lafayette, Indiana, United States of America
⨯
Andrew S. Torres,

Current address: Regeneron Pharmaceuticals, Inc., Rensselaer, New York, United States of America

Affiliation GE Global Research Center, Niskayuna, New York, United States of America
⨯
Antonio Caiafa,

Affiliation GE Global Research Center, Niskayuna, New York, United States of America
⨯
Christine A. Morton,

Affiliation GE Global Research Center, Niskayuna, New York, United States of America
⨯
Michelle A. Berny-Lang,

Affiliation Center for Platelet Research Studies, Division of Hematology/Oncology, Boston Children's Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Sabrina L. Carmichael,

Affiliation Center for Platelet Research Studies, Division of Hematology/Oncology, Boston Children's Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
V. Bogdan Neculaes ,

* E-mail: Andrew.Frelinger@childrens.harvard.edu (ALF); Neculaes@research.ge.com (VBN)

Affiliation GE Global Research Center, Niskayuna, New York, United States of America
⨯
Alan D. Michelson

Affiliation Center for Platelet Research Studies, Division of Hematology/Oncology, Boston Children's Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America
⨯

Modification of Pulsed Electric Field Conditions Results in Distinct Activation Profiles of Platelet-Rich Plasma

Andrew L. Frelinger III,
Anja J. Gerrits,
Allen L. Garner,
Andrew S. Torres,
Antonio Caiafa,
Christine A. Morton,
Michelle A. Berny-Lang,
Sabrina L. Carmichael,
V. Bogdan Neculaes,
Alan D. Michelson

Published: August 24, 2016
https://doi.org/10.1371/journal.pone.0160933

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Platelet activation
Is the Subject Area "Platelet activation" applicable to this article?

Thanks for your feedback.
Platelets
Is the Subject Area "Platelets" applicable to this article?

Thanks for your feedback.
Thrombin
Is the Subject Area "Thrombin" applicable to this article?

Thanks for your feedback.
Growth factors
Is the Subject Area "Growth factors" applicable to this article?

Thanks for your feedback.
Cell proliferation
Is the Subject Area "Cell proliferation" applicable to this article?

Thanks for your feedback.
Cell membranes
Is the Subject Area "Cell membranes" applicable to this article?

Thanks for your feedback.
Electric field
Is the Subject Area "Electric field" applicable to this article?

Thanks for your feedback.
Intracellular membranes
Is the Subject Area "Intracellular membranes" applicable to this article?

Thanks for your feedback.