Natural Cubic Spline Regression Modeling Followed by Dynamic Network Reconstruction for the Identification of Radiation-Sensitivity Gene Association Networks from Time-Course Transcriptome Data

Agata Michna; Herbert Braselmann; Martin Selmansberger; Anne Dietz; Julia Hess; Maria Gomolka; Sabine Hornhardt; Nils Blüthgen; Horst Zitzelsberger; Kristian Unger

doi:10.1371/journal.pone.0160791

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Peer-reviewed

Research Article

Natural Cubic Spline Regression Modeling Followed by Dynamic Network Reconstruction for the Identification of Radiation-Sensitivity Gene Association Networks from Time-Course Transcriptome Data

Agata Michna,

Affiliation Research Unit Radiation Cytogenetics, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, Neuherberg, Germany
⨯
Herbert Braselmann,

Affiliations Research Unit Radiation Cytogenetics, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, Neuherberg, Germany, Clinical Cooperation Group "Personalized Radiotherapy in Head and Neck Cancer", Helmholtz Zentrum München, Neuherberg, Germany
⨯
Martin Selmansberger,

Affiliation Research Unit Radiation Cytogenetics, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, Neuherberg, Germany
⨯
Anne Dietz,

Affiliation Department of Radiation Protection and Health, Federal Office for Radiation Protection, Neuherberg, Germany
⨯
Julia Hess,

Affiliations Research Unit Radiation Cytogenetics, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, Neuherberg, Germany, Clinical Cooperation Group "Personalized Radiotherapy in Head and Neck Cancer", Helmholtz Zentrum München, Neuherberg, Germany
⨯
Maria Gomolka,

Affiliation Department of Radiation Protection and Health, Federal Office for Radiation Protection, Neuherberg, Germany
⨯
Sabine Hornhardt,

Affiliation Department of Radiation Protection and Health, Federal Office for Radiation Protection, Neuherberg, Germany
⨯
Nils Blüthgen,

Affiliation Institute of Pathology, Charité—Universitätsmedizin Berlin, Berlin, Germany
⨯
Horst Zitzelsberger,

Affiliations Research Unit Radiation Cytogenetics, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, Neuherberg, Germany, Clinical Cooperation Group "Personalized Radiotherapy in Head and Neck Cancer", Helmholtz Zentrum München, Neuherberg, Germany
⨯
Kristian Unger

* E-mail: unger@helmholtz-muenchen.de

Affiliations Research Unit Radiation Cytogenetics, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, Neuherberg, Germany, Clinical Cooperation Group "Personalized Radiotherapy in Head and Neck Cancer", Helmholtz Zentrum München, Neuherberg, Germany
⨯

Natural Cubic Spline Regression Modeling Followed by Dynamic Network Reconstruction for the Identification of Radiation-Sensitivity Gene Association Networks from Time-Course Transcriptome Data

Agata Michna,
Herbert Braselmann,
Martin Selmansberger,
Anne Dietz,
Julia Hess,
Maria Gomolka,
Sabine Hornhardt,
Nils Blüthgen,
Horst Zitzelsberger,
Kristian Unger

Published: August 9, 2016
https://doi.org/10.1371/journal.pone.0160791

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Gene expression
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Genetic networks
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Radiation therapy
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Ionizing radiation
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Transcriptome analysis
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