Cardiomyocyte-Specific Ablation of Med1 Subunit of the Mediator Complex Causes Lethal Dilated Cardiomyopathy in Mice

Yuzhi Jia; Hsiang-Chun Chang; Matthew J. Schipma; Jing Liu; Varsha Shete; Ning Liu; Tatsuya Sato; Edward B. Thorp; Philip M. Barger; Yi-Jun Zhu; Navin Viswakarma; Yashpal S. Kanwar; Hossein Ardehali; Bayar Thimmapaya; Janardan K. Reddy

doi:10.1371/journal.pone.0160755

Loading metrics

Open Access

Peer-reviewed

Research Article

Cardiomyocyte-Specific Ablation of Med1 Subunit of the Mediator Complex Causes Lethal Dilated Cardiomyopathy in Mice

Yuzhi Jia,

Affiliation Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America
⨯
Hsiang-Chun Chang,

Affiliation Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America
⨯
Matthew J. Schipma,

Affiliation Next Generation Sequencing Core Facility, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America
⨯
Jing Liu,

Affiliation Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America
⨯
Varsha Shete,

Affiliation Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America
⨯
Ning Liu,

Affiliation Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America
⨯
Tatsuya Sato,

Affiliation Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America
⨯
Edward B. Thorp,

Affiliation Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America
⨯
Philip M. Barger,

Affiliation Center for Cardiovascular Research, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
Yi-Jun Zhu,

Affiliation Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America
⨯
Navin Viswakarma,

Affiliation Department of Surgery, University of Illinois at Chicago, Chicago, Illinois, United States of America
⨯
Yashpal S. Kanwar,

Affiliation Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America
⨯
Hossein Ardehali,

Affiliation Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America
⨯
Bayar Thimmapaya ,

* E-mail: jkreddy@northwestern.edu (JKR); b-thimmapaya@northwestern.edu (BT)

Affiliation Department of Microbiology and Immunology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America
⨯
Janardan K. Reddy

* E-mail: jkreddy@northwestern.edu (JKR); b-thimmapaya@northwestern.edu (BT)

Affiliation Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America
⨯

Cardiomyocyte-Specific Ablation of Med1 Subunit of the Mediator Complex Causes Lethal Dilated Cardiomyopathy in Mice

Yuzhi Jia,
Hsiang-Chun Chang,
Matthew J. Schipma,
Jing Liu,
Varsha Shete,
Ning Liu,
Tatsuya Sato,
Edward B. Thorp,
Philip M. Barger,
Yi-Jun Zhu

Published: August 22, 2016
https://doi.org/10.1371/journal.pone.0160755

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Heart
Is the Subject Area "Heart" applicable to this article?

Thanks for your feedback.
Gene expression
Is the Subject Area "Gene expression" applicable to this article?

Thanks for your feedback.
Mitochondria
Is the Subject Area "Mitochondria" applicable to this article?

Thanks for your feedback.
Cardiomyopathies
Is the Subject Area "Cardiomyopathies" applicable to this article?

Thanks for your feedback.
Genetically modified animals
Is the Subject Area "Genetically modified animals" applicable to this article?

Thanks for your feedback.
Mouse models
Is the Subject Area "Mouse models" applicable to this article?

Thanks for your feedback.
Calcium signaling
Is the Subject Area "Calcium signaling" applicable to this article?

Thanks for your feedback.
Fibrosis
Is the Subject Area "Fibrosis" applicable to this article?

Thanks for your feedback.