Cilostazol Modulates Autophagic Degradation of β-Amyloid Peptide via SIRT1-Coupled LKB1/AMPKα Signaling in Neuronal Cells

So Youn Park; Hye Rin Lee; Won Suk Lee; Hwa Kyoung Shin; Hye Young Kim; Ki Whan Hong; Chi Dae Kim

doi:10.1371/journal.pone.0160620

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Peer-reviewed

Research Article

Cilostazol Modulates Autophagic Degradation of β-Amyloid Peptide via SIRT1-Coupled LKB1/AMPKα Signaling in Neuronal Cells

So Youn Park ,

Contributed equally to this work with: So Youn Park, Hye Rin Lee

Affiliations Department of Pharmacology, School of Korean Medicine, Pusan National University, Gyeongsangnam-do, 50612, Republic of Korea, Gene & Cell Therapy Research Center for Vessel-associated Diseases, Pusan National University, Gyeongsangnam-do, 50612, Republic of Korea
⨯
Hye Rin Lee ,

Contributed equally to this work with: So Youn Park, Hye Rin Lee

Affiliation Gene & Cell Therapy Research Center for Vessel-associated Diseases, Pusan National University, Gyeongsangnam-do, 50612, Republic of Korea
⨯
Won Suk Lee,

Affiliation Department of Pharmacology, School of Korean Medicine, Pusan National University, Gyeongsangnam-do, 50612, Republic of Korea
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Hwa Kyoung Shin,

Affiliation Division of Meridian and Structural Medicine, Pusan National University, Gyeongsangnam-do, 50612, Republic of Korea
⨯
Hye Young Kim,

Affiliation Gene & Cell Therapy Research Center for Vessel-associated Diseases, Pusan National University, Gyeongsangnam-do, 50612, Republic of Korea
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Ki Whan Hong,

Affiliation Gene & Cell Therapy Research Center for Vessel-associated Diseases, Pusan National University, Gyeongsangnam-do, 50612, Republic of Korea
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Chi Dae Kim

* E-mail: chidkim@pusan.ac.kr

Affiliations Department of Pharmacology, School of Korean Medicine, Pusan National University, Gyeongsangnam-do, 50612, Republic of Korea, Gene & Cell Therapy Research Center for Vessel-associated Diseases, Pusan National University, Gyeongsangnam-do, 50612, Republic of Korea
⨯

Cilostazol Modulates Autophagic Degradation of β-Amyloid Peptide via SIRT1-Coupled LKB1/AMPKα Signaling in Neuronal Cells

So Youn Park,
Hye Rin Lee,
Won Suk Lee,
Hwa Kyoung Shin,
Hye Young Kim,
Ki Whan Hong,
Chi Dae Kim

Published: August 5, 2016
https://doi.org/10.1371/journal.pone.0160620

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