RNAseq Analyses Identify Tumor Necrosis Factor-Mediated Inflammation as a Major Abnormality in ALS Spinal Cord

Open Access

Peer-reviewed

Research Article

David G. Brohawn,

Affiliations Parkinson’s Disease Research Center, Virginia Commonwealth University, Richmond, Virginia, United States of America, Department of Human Genetics, Virginia Commonwealth University, Richmond, Virginia, United States of America
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Laura C. O’Brien,

Affiliations Parkinson’s Disease Research Center, Virginia Commonwealth University, Richmond, Virginia, United States of America, Department of Physiology and Biophysics, Virginia Commonwealth University, Richmond, Virginia, United States of America
⨯
James P. Bennett Jr.

* E-mail: aging.mitochondria@gmail.com

Affiliations Parkinson’s Disease Research Center, Virginia Commonwealth University, Richmond, Virginia, United States of America, Department of Physiology and Biophysics, Virginia Commonwealth University, Richmond, Virginia, United States of America, Department of Neurology; Virginia Commonwealth University, Richmond, Virginia, United States of America, Neurodegeneration Therapeutics, Inc., Charlottesville, Virginia, United States of America
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Cytokines
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Motor neurons
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Amyotrophic lateral sclerosis
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Gene expression
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Sequence alignment
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Genetic networks
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Inflammation
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Gene regulatory networks
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