Outer Membrane Vesicles from the Probiotic Escherichia coli Nissle 1917 and the Commensal ECOR12 Enter Intestinal Epithelial Cells via Clathrin-Dependent Endocytosis and Elicit Differential Effects on DNA Damage

María-Alexandra Cañas; Rosa Giménez; María-José Fábrega; Lorena Toloza; Laura Baldomà; Josefa Badia

doi:10.1371/journal.pone.0160374

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Research Article

Outer Membrane Vesicles from the Probiotic Escherichia coli Nissle 1917 and the Commensal ECOR12 Enter Intestinal Epithelial Cells via Clathrin-Dependent Endocytosis and Elicit Differential Effects on DNA Damage

María-Alexandra Cañas,

Affiliations Secció de Bioquímica i Biología Molecular, Departament de Bioquímica i Fisiologia, Facultat de Farmàcia, Universitat de Barcelona, Barcelona, Spain, Institut de Biomedicina de la Universitat de Barcelona, Barcelona, Spain
⨯
Rosa Giménez,

Affiliations Secció de Bioquímica i Biología Molecular, Departament de Bioquímica i Fisiologia, Facultat de Farmàcia, Universitat de Barcelona, Barcelona, Spain, Institut de Biomedicina de la Universitat de Barcelona, Barcelona, Spain
⨯
María-José Fábrega,

Affiliations Secció de Bioquímica i Biología Molecular, Departament de Bioquímica i Fisiologia, Facultat de Farmàcia, Universitat de Barcelona, Barcelona, Spain, Institut de Biomedicina de la Universitat de Barcelona, Barcelona, Spain
⨯
Lorena Toloza,

Current address: Departamento de Microbiología, Facultad de Ciencias de la Salud, Universidad de Talca, Talca, Chile

Affiliation Secció de Bioquímica i Biología Molecular, Departament de Bioquímica i Fisiologia, Facultat de Farmàcia, Universitat de Barcelona, Barcelona, Spain
⨯
Laura Baldomà ,

* E-mail: lbaldoma@ub.edu

Affiliations Secció de Bioquímica i Biología Molecular, Departament de Bioquímica i Fisiologia, Facultat de Farmàcia, Universitat de Barcelona, Barcelona, Spain, Institut de Biomedicina de la Universitat de Barcelona, Barcelona, Spain

http://orcid.org/0000-0002-7678-269X

⨯
Josefa Badia

Affiliations Secció de Bioquímica i Biología Molecular, Departament de Bioquímica i Fisiologia, Facultat de Farmàcia, Universitat de Barcelona, Barcelona, Spain, Institut de Biomedicina de la Universitat de Barcelona, Barcelona, Spain
⨯

Outer Membrane Vesicles from the Probiotic Escherichia coli Nissle 1917 and the Commensal ECOR12 Enter Intestinal Epithelial Cells via Clathrin-Dependent Endocytosis and Elicit Differential Effects on DNA Damage

María-Alexandra Cañas,
Rosa Giménez,
María-José Fábrega,
Lorena Toloza,
Laura Baldomà,
Josefa Badia

Published: August 3, 2016
https://doi.org/10.1371/journal.pone.0160374

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Vesicles
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Endocytosis
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Gut bacteria
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Gastrointestinal tract
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Epithelial cells
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DNA damage
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