Generation and Characterization of an IgG4 Monomeric Fc Platform

Lu Shan; Magali Colazet; Kim L. Rosenthal; Xiang-Qing Yu; Jared S. Bee; Andrew Ferguson; Melissa M. Damschroder; Herren Wu; William F. Dall’Acqua; Ping Tsui; Vaheh Oganesyan

doi:10.1371/journal.pone.0160345

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Open Access

Peer-reviewed

Research Article

Generation and Characterization of an IgG4 Monomeric Fc Platform

Lu Shan,

Affiliation Antibody Discovery and Protein Engineering, MedImmune, Gaithersburg, Maryland, United States of America
⨯
Magali Colazet,

Affiliation Antibody Discovery and Protein Engineering, MedImmune, Gaithersburg, Maryland, United States of America
⨯
Kim L. Rosenthal,

Affiliation Antibody Discovery and Protein Engineering, MedImmune, Gaithersburg, Maryland, United States of America
⨯
Xiang-Qing Yu,

Affiliation Clinical Pharmacology and Drug Metabolism and Pharmacokinetics, MedImmune, Gaithersburg, Maryland, United States of America
⨯
Jared S. Bee,

Affiliation Analytical Biotechnology, MedImmune, Gaithersburg, Maryland, United States of America
⨯
Andrew Ferguson,

Affiliation Discovery Sciences, Structure and Biophysics, AstraZeneca Pharmaceuticals, Waltham, Massachusetts, United States of America
⨯
Melissa M. Damschroder,

Affiliation Antibody Discovery and Protein Engineering, MedImmune, Gaithersburg, Maryland, United States of America
⨯
Herren Wu,

Affiliation Antibody Discovery and Protein Engineering, MedImmune, Gaithersburg, Maryland, United States of America
⨯
William F. Dall’Acqua,

Affiliation Antibody Discovery and Protein Engineering, MedImmune, Gaithersburg, Maryland, United States of America
⨯
Ping Tsui ,

* E-mail: TsuiP@medimmune.com (PT); OganesyanV@MedImmune.com (OV)

Affiliation Antibody Discovery and Protein Engineering, MedImmune, Gaithersburg, Maryland, United States of America
⨯
Vaheh Oganesyan

* E-mail: TsuiP@medimmune.com (PT); OganesyanV@MedImmune.com (OV)

Affiliation Antibody Discovery and Protein Engineering, MedImmune, Gaithersburg, Maryland, United States of America

http://orcid.org/0000-0001-8910-9202

⨯

Generation and Characterization of an IgG4 Monomeric Fc Platform

Lu Shan,
Magali Colazet,
Kim L. Rosenthal,
Xiang-Qing Yu,
Jared S. Bee,
Andrew Ferguson,
Melissa M. Damschroder,
Herren Wu,
William F. Dall’Acqua,
Ping Tsui

Published: August 1, 2016
https://doi.org/10.1371/journal.pone.0160345

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