Up-Regulation of CYP2C19 Expression by BuChang NaoXinTong via PXR Activation in HepG2 Cells

Hong Sun; Xiao-Ya Lou; Xiao-Ying Wu; Huan Wang; Qiang Qu; Shen-Lan Tan; Jun-Shan Ruan; Jian Qu; Hui Chen

doi:10.1371/journal.pone.0160285

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Open Access

Peer-reviewed

Research Article

Up-Regulation of CYP2C19 Expression by BuChang NaoXinTong via PXR Activation in HepG2 Cells

Hong Sun ,

Contributed equally to this work with: Hong Sun, Xiao-Ya Lou

Affiliation Department of Pharmacy, Provincial Clinical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou, Fujan, P. R. China
⨯
Xiao-Ya Lou ,

Contributed equally to this work with: Hong Sun, Xiao-Ya Lou

Affiliation Department of Clinical Pharmacology, Xiangya Hospital and Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, Changsha, Hunan, P. R. China
⨯
Xiao-Ying Wu,

Affiliation Hypertension Laboratory, Provincial Clinical College of Fujian Medical University, Fujian Provincial Cardiovascular Disease Institute, Fujian Provincial Hospital, Fuzhou, Fujian, P. R. China
⨯
Huan Wang,

Affiliation Hypertension Laboratory, Provincial Clinical College of Fujian Medical University, Fujian Provincial Cardiovascular Disease Institute, Fujian Provincial Hospital, Fuzhou, Fujian, P. R. China
⨯
Qiang Qu,

Affiliation Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, Hunan, P. R. China
⨯
Shen-Lan Tan,

Affiliation Department of Pharmacy, the Second Xiangya Hospital, Central South University; Institute of Clinical Pharmacy, Central South University, Changsha, Hunan, P. R. China
⨯
Jun-Shan Ruan,

Affiliation Department of Pharmacy, Provincial Clinical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou, Fujan, P. R. China
⨯
Jian Qu ,

* E-mail: qujian@csu.edu.cn (JQ); chenhuiwyd@sina.com (HC)

Affiliation Department of Pharmacy, the Second Xiangya Hospital, Central South University; Institute of Clinical Pharmacy, Central South University, Changsha, Hunan, P. R. China
⨯
Hui Chen

* E-mail: qujian@csu.edu.cn (JQ); chenhuiwyd@sina.com (HC)

Affiliation Hypertension Laboratory, Provincial Clinical College of Fujian Medical University, Fujian Provincial Cardiovascular Disease Institute, Fujian Provincial Hospital, Fuzhou, Fujian, P. R. China
⨯

Up-Regulation of CYP2C19 Expression by BuChang NaoXinTong via PXR Activation in HepG2 Cells

Hong Sun,
Xiao-Ya Lou,
Xiao-Ying Wu,
Huan Wang,
Qiang Qu,
Shen-Lan Tan,
Jun-Shan Ruan,
Jian Qu,
Hui Chen

Published: July 28, 2016
https://doi.org/10.1371/journal.pone.0160285

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