Insight on Mutation-Induced Resistance from Molecular Dynamics Simulations of the Native and Mutated CSF-1R and KIT

Priscila Da Silva Figueiredo Celestino Gomes; Isaure Chauvot De Beauchêne; Nicolas Panel; Sophie Lopez; Paulo De Sepulveda; Pedro Geraldo Pascutti; Eric Solary; Luba Tchertanov

doi:10.1371/journal.pone.0160165

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Peer-reviewed

Research Article

Insight on Mutation-Induced Resistance from Molecular Dynamics Simulations of the Native and Mutated CSF-1R and KIT

Priscila Da Silva Figueiredo Celestino Gomes,

Affiliations Laboratoire de Biologie et Pharmacologie Appliquée (LBPA), ENS Cachan, CNRS, Université, Paris-Saclay, 94235 Cachan, France, Laboratório de Modelagem e Dinâmica Molecular, Instituto de Biofísica Carlos Chagas FilhoUniversidade Federal do Rio de Janeiro, 373 av. Carlos Chagas Filho, 21941-902, Rio de Janeiro, Brazil
⨯
Isaure Chauvot De Beauchêne,

Current address: Physik-Department (T38), Technische Universität München, James-Franck-Str. 1, 85748 Garching, Germany

Affiliation Laboratoire de Biologie et Pharmacologie Appliquée (LBPA), ENS Cachan, CNRS, Université, Paris-Saclay, 94235 Cachan, France
⨯
Nicolas Panel,

Affiliation Laboratoire de Biologie et Pharmacologie Appliquée (LBPA), ENS Cachan, CNRS, Université, Paris-Saclay, 94235 Cachan, France
⨯
Sophie Lopez,

Affiliation INSERM U1068, Centre de Recherche en Cancérologie de Marseille, 13009 Marseille, France
⨯
Paulo De Sepulveda,

Affiliation INSERM U1068, Centre de Recherche en Cancérologie de Marseille, 13009 Marseille, France
⨯
Pedro Geraldo Pascutti,

Affiliation Laboratório de Modelagem e Dinâmica Molecular, Instituto de Biofísica Carlos Chagas FilhoUniversidade Federal do Rio de Janeiro, 373 av. Carlos Chagas Filho, 21941-902, Rio de Janeiro, Brazil
⨯
Eric Solary,

Affiliations Inserm UMR1170, Gustave Roussy, 114 rue Edouard Vaillant, 94805 Villejuif cedex, France, Paris-Sud University, Faculty of Medicine, Le Kremlin-Bicêtre, France
⨯
Luba Tchertanov

* E-mail: Luba.Tchertanov@ens-cachan.fr

Affiliations Laboratoire de Biologie et Pharmacologie Appliquée (LBPA), ENS Cachan, CNRS, Université, Paris-Saclay, 94235 Cachan, France, Centre de Mathématiques et de Leurs Applications, (CMLA), ENS Cachan, CNRS, Université, Paris-Saclay, 94235 Cachan, France
⨯

Insight on Mutation-Induced Resistance from Molecular Dynamics Simulations of the Native and Mutated CSF-1R and KIT

Priscila Da Silva Figueiredo Celestino Gomes,
Isaure Chauvot De Beauchêne,
Nicolas Panel,
Sophie Lopez,
Paulo De Sepulveda,
Pedro Geraldo Pascutti,
Eric Solary,
Luba Tchertanov

Published: July 28, 2016
https://doi.org/10.1371/journal.pone.0160165

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