Cobalt Alloy Implant Debris Induces Inflammation and Bone Loss Primarily through Danger Signaling, Not TLR4 Activation: Implications for DAMP-ening Implant Related Inflammation

Open Access

Peer-reviewed

Research Article

Lauryn Samelko,

Affiliations Department of Orthopedic Surgery, Rush University Medical Center, Chicago, Illinois, United States of America, Department of Immunology, Rush University Medical Center, Chicago, Illinois, United States of America
⨯
Stefan Landgraeber,

Affiliation Department of Orthopaedics, University Hospital Essen, University of Duisburg-Essen, Hufelandstrabe 55, 45122, Essen, Germany
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Kyron McAllister,

Affiliation Department of Orthopedic Surgery, Rush University Medical Center, Chicago, Illinois, United States of America
⨯
Joshua Jacobs,

Affiliation Department of Orthopedic Surgery, Rush University Medical Center, Chicago, Illinois, United States of America
⨯
Nadim James Hallab

* E-mail: nhallab@rush.edu

Affiliation Department of Orthopedic Surgery, Rush University Medical Center, Chicago, Illinois, United States of America
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Cobalt alloys
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Inflammation
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Cobalt
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Macrophages
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Inflammasomes
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Immune receptor signaling
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Medical implants
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Toll-like receptors
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