Pharmacokinetics in Wistar Rats of 5-[(4-Carboxybutanoyl)Amino]-2-Hydroxybenzoic Acid: A Novel Synthetic Derivative of 5-Aminosalicylic Acid (5-ASA) with Possible Anti-Inflammatory Activity

Aurelio Romero-Castro; Mara Gutiérrez-Sánchez; José Correa-Basurto; Martha Cecilia Rosales Hernández; Itzia Irene Padilla Martínez; Jessica Elena Mendieta-Wejebe

doi:10.1371/journal.pone.0159889

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Pharmacokinetics in Wistar Rats of 5-[(4-Carboxybutanoyl)Amino]-2-Hydroxybenzoic Acid: A Novel Synthetic Derivative of 5-Aminosalicylic Acid (5-ASA) with Possible Anti-Inflammatory Activity

Aurelio Romero-Castro ,

Contributed equally to this work with: Aurelio Romero-Castro, Mara Gutiérrez-Sánchez

Affiliation Laboratorio de Biofísica y Biocatálisis, Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Plan de San Luis y Salvador Díaz Mirón s/n, Casco de Santo Tomás, Ciudad de México 11340, México
⨯
Mara Gutiérrez-Sánchez ,

Contributed equally to this work with: Aurelio Romero-Castro, Mara Gutiérrez-Sánchez

Affiliation Laboratorio de Biofísica y Biocatálisis, Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Plan de San Luis y Salvador Díaz Mirón s/n, Casco de Santo Tomás, Ciudad de México 11340, México
⨯
José Correa-Basurto,

Affiliation Laboratorio de Modelado Molecular y Bioinformática, Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Plan de San Luis y Salvador Díaz Mirón s/n, Casco de Santo Tomás, Ciudad de México 11340, México
⨯
Martha Cecilia Rosales Hernández,

Affiliation Laboratorio de Biofísica y Biocatálisis, Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Plan de San Luis y Salvador Díaz Mirón s/n, Casco de Santo Tomás, Ciudad de México 11340, México
⨯
Itzia Irene Padilla Martínez,

Affiliation Laboratorio de Química Supramolecular y Orgánica, Departamento de Ciencias Básicas, Unidad Profesional Interdisciplinaria de Biotecnología, Instituto Politécnico Nacional, Av. Acueducto s/n, Barrio La Laguna Ticomán, Ciudad de México 07340, México
⨯
Jessica Elena Mendieta-Wejebe

* E-mail: jesmenwej@yahoo.com

Affiliation Laboratorio de Biofísica y Biocatálisis, Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Plan de San Luis y Salvador Díaz Mirón s/n, Casco de Santo Tomás, Ciudad de México 11340, México
⨯

Pharmacokinetics in Wistar Rats of 5-[(4-Carboxybutanoyl)Amino]-2-Hydroxybenzoic Acid: A Novel Synthetic Derivative of 5-Aminosalicylic Acid (5-ASA) with Possible Anti-Inflammatory Activity

Aurelio Romero-Castro,
Mara Gutiérrez-Sánchez,
José Correa-Basurto,
Martha Cecilia Rosales Hernández,
Itzia Irene Padilla Martínez,
Jessica Elena Mendieta-Wejebe

Published: July 25, 2016
https://doi.org/10.1371/journal.pone.0159889

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