Extracellular pH Modulates Neuroendocrine Prostate Cancer Cell Metabolism and Susceptibility to the Mitochondrial Inhibitor Niclosamide

Joseph E. Ippolito; Matthew W. Brandenburg; Xia Ge; Jan R. Crowley; Kristopher M. Kirmess; Avik Som; D. Andre D’Avignon; Jeffrey M. Arbeit; Samuel Achilefu; Kevin E. Yarasheski; Jeffrey Milbrandt

doi:10.1371/journal.pone.0159675

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Open Access

Peer-reviewed

Research Article

Extracellular pH Modulates Neuroendocrine Prostate Cancer Cell Metabolism and Susceptibility to the Mitochondrial Inhibitor Niclosamide

Joseph E. Ippolito ,

* E-mail: ippolitoj@wustl.edu

Affiliations Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri, United States of America, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
Matthew W. Brandenburg,

Affiliations Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri, United States of America, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
Xia Ge,

Affiliation Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
Jan R. Crowley,

Affiliation Biomedical Mass Spectrometry Resource, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
Kristopher M. Kirmess,

Affiliation Biomedical Mass Spectrometry Resource, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
Avik Som,

Affiliation Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
D. Andre D’Avignon,

Affiliation Sanford Burnham Prebys Medical Discovery Institute, Orlando, Florida, United States of America
⨯
Jeffrey M. Arbeit,

Affiliation Department of Surgery, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
Samuel Achilefu,

Affiliation Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
Kevin E. Yarasheski,

Affiliation Biomedical Mass Spectrometry Resource, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
Jeffrey Milbrandt

Affiliation Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯

Extracellular pH Modulates Neuroendocrine Prostate Cancer Cell Metabolism and Susceptibility to the Mitochondrial Inhibitor Niclosamide

Joseph E. Ippolito,
Matthew W. Brandenburg,
Xia Ge,
Jan R. Crowley,
Kristopher M. Kirmess,
Avik Som,
D. Andre D’Avignon,
Jeffrey M. Arbeit,
Samuel Achilefu,
Kevin E. Yarasheski

Published: July 20, 2016
https://doi.org/10.1371/journal.pone.0159675

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