Electronic Health Record Based Algorithm to Identify Patients with Autism Spectrum Disorder

Todd Lingren; Pei Chen; Joseph Bochenek; Finale Doshi-Velez; Patty Manning-Courtney; Julie Bickel; Leah Wildenger Welchons; Judy Reinhold; Nicole Bing; Yizhao Ni; William Barbaresi; Frank Mentch; Melissa Basford; Joshua Denny; Lyam Vazquez; Cassandra Perry; Bahram Namjou; Haijun Qiu; John Connolly; Debra Abrams; Ingrid A. Holm; Beth A. Cobb; Nataline Lingren; Imre Solti; Hakon Hakonarson; Isaac S. Kohane; John Harley; Guergana Savova

doi:10.1371/journal.pone.0159621

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Open Access

Peer-reviewed

Research Article

Electronic Health Record Based Algorithm to Identify Patients with Autism Spectrum Disorder

Todd Lingren ,

* E-mail: todd.lingren@cchmc.org

Affiliation Cincinnati Children's Hospital Medical Center, Division of Biomedical Informatics, Cincinnati, Ohio, United States of America

http://orcid.org/0000-0003-0311-7100

⨯
Pei Chen,

Affiliation Boston Children's Hospital, Center for Systems Biology, Boston, Massachusetts, United States of America
⨯
Joseph Bochenek,

Affiliation Vanderbilt University School of Medicine, Biomedical Informatics, Nashville, Tennessee, United States of America
⨯
Finale Doshi-Velez,

Affiliation Harvard Medical School, Center for Biomedical Informatics, Boston, Massachusetts, United States of America
⨯
Patty Manning-Courtney,

Affiliations University of Cincinnati, Department of Pediatrics, Cincinnati, Ohio, United States of America, Cincinnati Children’s Hospital Medical Center, Division of Developmental and Behavioral Pediatrics, Cincinnati, Ohio, United States of America
⨯
Julie Bickel,

Affiliations Boston Children's Hospital, Pediatrics, Boston, Massachusetts, United States of America, Boston Children's Hospital, Developmental Medicine, Boston, Massachusetts, United States of America
⨯
Leah Wildenger Welchons,

Affiliations Boston Children's Hospital, Pediatrics, Boston, Massachusetts, United States of America, Boston Children's Hospital, Developmental Medicine, Boston, Massachusetts, United States of America, Boston Children's Hospital, Neurology and Center for Communication Enhancement, Boston, Massachusetts, United States of America
⨯
Judy Reinhold,

Affiliations University of Cincinnati, Department of Pediatrics, Cincinnati, Ohio, United States of America, Cincinnati Children’s Hospital Medical Center, Division of Developmental and Behavioral Pediatrics, Cincinnati, Ohio, United States of America
⨯
Nicole Bing,

Affiliations University of Cincinnati, Department of Pediatrics, Cincinnati, Ohio, United States of America, Cincinnati Children’s Hospital Medical Center, Division of Developmental and Behavioral Pediatrics, Cincinnati, Ohio, United States of America
⨯
Yizhao Ni,

Affiliation Cincinnati Children's Hospital Medical Center, Division of Biomedical Informatics, Cincinnati, Ohio, United States of America
⨯
William Barbaresi,

Affiliation Children's Hospital Boston, Division of Medicine, Boston, Massachusetts, United States of America
⨯
Frank Mentch,

Affiliation Children's Hospital of Philadelphia, Center for Applied Genomics, Philadelphia, Pennsylvania, United States of America
⨯
Melissa Basford,

Affiliation Vanderbilt University Medical Center, Vanderbilt Institute for Clinical and Translational Research, Nashville, Tennessee, United States of America
⨯
Joshua Denny,

Affiliation Vanderbilt University School of Medicine, Biomedical Informatics, Nashville, Tennessee, United States of America
⨯
Lyam Vazquez,

Affiliation Children's Hospital of Philadelphia, Center for Applied Genomics, Philadelphia, Pennsylvania, United States of America
⨯
Cassandra Perry,

Affiliation Boston Children's Hospital, Division of Genetics and Genomics, Boston, Massachusetts, United States of America
⨯
Bahram Namjou,

Affiliations Cincinnati Children's Hospital Medical Center, Center for Autoimmune Genomics and Etiology, Cincinnati, Ohio, United States of America, University of Cincinnati, College of Medicine, Cincinnati, Ohio, United States of America
⨯
Haijun Qiu,

Affiliation Children's Hospital of Philadelphia, Center for Applied Genomics, Philadelphia, Pennsylvania, United States of America
⨯
John Connolly,

Affiliation Children's Hospital of Philadelphia, Center for Applied Genomics, Philadelphia, Pennsylvania, United States of America
⨯
Debra Abrams,

Affiliation Children's Hospital of Philadelphia, Center for Applied Genomics, Philadelphia, Pennsylvania, United States of America
⨯
Ingrid A. Holm,

Affiliations Children's Hospital Boston, Division of Medicine, Boston, Massachusetts, United States of America, Boston Children's Hospital, Division of Genetics and Genomics, Boston, Massachusetts, United States of America, Harvard Medical School, Pediatrics, Boston, Massachusetts, United States of America, Boston Children's Hospital, Manton Center for Orphan Disease Research, Boston, Massachusetts, United States of America
⨯
Beth A. Cobb,

Affiliation Cincinnati Children's Hospital Medical Center, Center for Autoimmune Genomics and Etiology, Cincinnati, Ohio, United States of America
⨯
Nataline Lingren,

Affiliation Cincinnati Children’s Hospital Medical Center, Emergency Medicine, Cincinnati, Ohio, United States of America
⨯
Imre Solti,

Affiliations Cincinnati Children's Hospital Medical Center, Division of Biomedical Informatics, Cincinnati, Ohio, United States of America, University of Cincinnati, College of Medicine, Cincinnati, Ohio, United States of America
⨯
Hakon Hakonarson,

Affiliations Children's Hospital of Philadelphia, Center for Applied Genomics, Philadelphia, Pennsylvania, United States of America, Perelman School of Medicine, Pediatrics, Philadelphia, Pennsylvania, United States of America
⨯
Isaac S. Kohane,

Affiliations Harvard Medical School, Pediatrics, Boston, Massachusetts, United States of America, Boston Children's Hospital, Children’s Hospital Informatics Program, Boston, Massachusetts, United States of America
⨯
John Harley,

Affiliations University of Cincinnati, Department of Pediatrics, Cincinnati, Ohio, United States of America, Cincinnati Children's Hospital Medical Center, Center for Autoimmune Genomics and Etiology, Cincinnati, Ohio, United States of America, United States Department of Veterans Affairs Medical Center, Medicine, Cincinnati, Ohio, United States of America
⨯
[ ... ],
Guergana Savova

Affiliations Harvard Medical School, Pediatrics, Boston, Massachusetts, United States of America, Boston Children's Hospital, Children’s Hospital Informatics Program, Boston, Massachusetts, United States of America
⨯
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Electronic Health Record Based Algorithm to Identify Patients with Autism Spectrum Disorder

Todd Lingren,
Pei Chen,
Joseph Bochenek,
Finale Doshi-Velez,
Patty Manning-Courtney,
Julie Bickel,
Leah Wildenger Welchons,
Judy Reinhold,
Nicole Bing,
Yizhao Ni

Published: July 29, 2016
https://doi.org/10.1371/journal.pone.0159621

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