Preclinical Evaluation of the Novel BTK Inhibitor Acalabrutinib in Canine Models of B-Cell Non-Hodgkin Lymphoma

• Bonnie K. Harrington ,

  ¶‡ BH and HG are co-first authors and contributed equally to this work. AJ and WK are co-senior authors and contributed equally to this work.

  Affiliation Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio, United States of America

  http://orcid.org/0000-0003-2658-6188

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• Heather L. Gardner ,

  ¶‡ BH and HG are co-first authors and contributed equally to this work. AJ and WK are co-senior authors and contributed equally to this work.

  Affiliation Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio, United States of America

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• Raquel Izumi,

  Affiliation Acerta Pharma BV, Oss, Netherlands

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• Ahmed Hamdy,

  Affiliation Acerta Pharma BV, Oss, Netherlands

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• Wayne Rothbaum,

  Affiliation Acerta Pharma BV, Oss, Netherlands

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• Kevin R. Coombes,

  Affiliation Department of Biomedical Informatics, College of Medicine, The Ohio State University, Columbus, Ohio, United States of America

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• Todd Covey,

  Affiliation Acerta Pharma BV, Oss, Netherlands

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• Allard Kaptein,

  Affiliation Acerta Pharma BV, Oss, Netherlands

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• Michael Gulrajani,

  Affiliation Acerta Pharma BV, Oss, Netherlands

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• Bart Van Lith,

  Affiliation Acerta Pharma BV, Oss, Netherlands

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• Cecile Krejsa,

  Affiliation Acerta Pharma BV, Oss, Netherlands

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• Christopher C. Coss,

  Affiliation Division of Pharmaceutics and Pharmaceutical Chemistry, College of Pharmacy, The Ohio State University, Columbus, Ohio, United States of America

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• Duncan S. Russell,

  Affiliation Department of Biomedical Sciences, College of Veterinary Medicine, Oregon State University, Corvallis, Oregon, United States of America

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• Xiaoli Zhang,

  Affiliation Center for Biostatistics, The Ohio State University, Columbus, Ohio, United States of America

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• Bridget K. Urie,

  Affiliation Pittsburgh Veterinary Specialty and Emergency Center, Pittsburgh, Pennsylvania, United States of America

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• Cheryl A. London,

  Affiliations Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio, United States of America, Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio, United States of America

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• John C. Byrd,

  Affiliation Division of Hematology, Department of Internal Medicine, College of Medicine, The Ohio State University, Columbus, Ohio, United States of America

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• Amy J. Johnson ,

  * E-mail: amy.johnson@osumc.edu (AJ); kisseberth.2@osu.edu (WK)

  ¶‡ BH and HG are co-first authors and contributed equally to this work. AJ and WK are co-senior authors and contributed equally to this work.

  Affiliation Division of Hematology, Department of Internal Medicine, College of Medicine, The Ohio State University, Columbus, Ohio, United States of America

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•  [ ... ],
• William C. Kisseberth

  * E-mail: amy.johnson@osumc.edu (AJ); kisseberth.2@osu.edu (WK)

  ¶‡ BH and HG are co-first authors and contributed equally to this work. AJ and WK are co-senior authors and contributed equally to this work.

  Affiliation Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio, United States of America

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