Utilisation of ISA Reverse Genetics and Large-Scale Random Codon Re-Encoding to Produce Attenuated Strains of Tick-Borne Encephalitis Virus within Days

• Lauriane de Fabritus ,

  Contributed equally to this work with: Lauriane de Fabritus, Antoine Nougairède

  Affiliation UMR "Emergence des Pathologies Virales" (EPV: Aix-Marseille University—IRD 190—Inserm 1207—EHESP), Marseille, France

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• Antoine Nougairède ,

  Contributed equally to this work with: Lauriane de Fabritus, Antoine Nougairède

  * E-mail: antoine.nougairede@univ-amu.fr

  Affiliations UMR "Emergence des Pathologies Virales" (EPV: Aix-Marseille University—IRD 190—Inserm 1207—EHESP), Marseille, France, Institut Hospitalo-Universitaire Méditerranée Infection, Marseille, France

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• Fabien Aubry,

  Affiliation UMR "Emergence des Pathologies Virales" (EPV: Aix-Marseille University—IRD 190—Inserm 1207—EHESP), Marseille, France

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• Ernest A. Gould,

  Affiliation UMR "Emergence des Pathologies Virales" (EPV: Aix-Marseille University—IRD 190—Inserm 1207—EHESP), Marseille, France

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• Xavier de Lamballerie

  Affiliations UMR "Emergence des Pathologies Virales" (EPV: Aix-Marseille University—IRD 190—Inserm 1207—EHESP), Marseille, France, Institut Hospitalo-Universitaire Méditerranée Infection, Marseille, France

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