Mild Alkalization Acutely Triggers the Warburg Effect by Enhancing Hexokinase Activity via Voltage-Dependent Anion Channel Binding

Cung Hoa Thien Quach; Kyung-Ho Jung; Jin Hee Lee; Jin Won Park; Seung Hwan Moon; Young Seok Cho; Yearn Seong Choe; Kyung-Han Lee

doi:10.1371/journal.pone.0159529

Loading metrics

Open Access

Peer-reviewed

Research Article

Mild Alkalization Acutely Triggers the Warburg Effect by Enhancing Hexokinase Activity via Voltage-Dependent Anion Channel Binding

Cung Hoa Thien Quach ,

Contributed equally to this work with: Cung Hoa Thien Quach, Kyung-Ho Jung

Affiliation Department of Nuclear Medicine, Samsung Medical Center, Seoul, Korea
⨯
Kyung-Ho Jung ,

Contributed equally to this work with: Cung Hoa Thien Quach, Kyung-Ho Jung

Affiliations Department of Nuclear Medicine, Samsung Medical Center, Seoul, Korea, Samsung Advanced Institute for Health Sciences & Technology, Sungkyunkwan University School of Medicine, Seoul, Korea
⨯
Jin Hee Lee,

Affiliations Department of Nuclear Medicine, Samsung Medical Center, Seoul, Korea, Samsung Advanced Institute for Health Sciences & Technology, Sungkyunkwan University School of Medicine, Seoul, Korea
⨯
Jin Won Park,

Affiliations Department of Nuclear Medicine, Samsung Medical Center, Seoul, Korea, Samsung Advanced Institute for Health Sciences & Technology, Sungkyunkwan University School of Medicine, Seoul, Korea
⨯
Seung Hwan Moon,

Affiliation Department of Nuclear Medicine, Samsung Medical Center, Seoul, Korea
⨯
Young Seok Cho,

Affiliation Department of Nuclear Medicine, Samsung Medical Center, Seoul, Korea
⨯
Yearn Seong Choe,

Affiliations Department of Nuclear Medicine, Samsung Medical Center, Seoul, Korea, Samsung Advanced Institute for Health Sciences & Technology, Sungkyunkwan University School of Medicine, Seoul, Korea
⨯
Kyung-Han Lee

* E-mail: khnm.lee@samsung.com

Affiliations Department of Nuclear Medicine, Samsung Medical Center, Seoul, Korea, Samsung Advanced Institute for Health Sciences & Technology, Sungkyunkwan University School of Medicine, Seoul, Korea
⨯

Mild Alkalization Acutely Triggers the Warburg Effect by Enhancing Hexokinase Activity via Voltage-Dependent Anion Channel Binding

Cung Hoa Thien Quach,
Kyung-Ho Jung,
Jin Hee Lee,
Jin Won Park,
Seung Hwan Moon,
Young Seok Cho,
Yearn Seong Choe,
Kyung-Han Lee

Published: August 1, 2016
https://doi.org/10.1371/journal.pone.0159529

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Mitochondria
Is the Subject Area "Mitochondria" applicable to this article?

Thanks for your feedback.
Breast cancer
Is the Subject Area "Breast cancer" applicable to this article?

Thanks for your feedback.
Small interfering RNA
Is the Subject Area "Small interfering RNA" applicable to this article?

Thanks for your feedback.
Glucose
Is the Subject Area "Glucose" applicable to this article?

Thanks for your feedback.
Transfection
Is the Subject Area "Transfection" applicable to this article?

Thanks for your feedback.
Cancers and neoplasms
Is the Subject Area "Cancers and neoplasms" applicable to this article?

Thanks for your feedback.
Warburg effect
Is the Subject Area "Warburg effect" applicable to this article?

Thanks for your feedback.
Hexokinases
Is the Subject Area "Hexokinases" applicable to this article?

Thanks for your feedback.