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Open Access
Peer-reviewed
Research Article
Fractionated Radiotherapy with 3 x 8 Gy Induces Systemic Anti-Tumour Responses and Abscopal Tumour Inhibition without Modulating the Humoral Anti-Tumour Response
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Thomas H. P. M. Habets,
Affiliations Division of Hematology, Department of Internal Medicine, GROW—School for Oncology and Developmental Biology, Maastricht University Medical Center +, Maastricht, The Netherlands, Tissue Typing Laboratory, Department of Transplantation Immunology, GROW—School for Oncology and Developmental Biology, Maastricht University Medical Center +, Maastricht, The Netherlands
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Tammy Oth,
Affiliation Division of Hematology, Department of Internal Medicine, GROW—School for Oncology and Developmental Biology, Maastricht University Medical Center +, Maastricht, The Netherlands
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Ans W. Houben,
Affiliations Division of Hematology, Department of Internal Medicine, GROW—School for Oncology and Developmental Biology, Maastricht University Medical Center +, Maastricht, The Netherlands, Division of Nuclear Medicine, Department of Internal Medicine, School of NUTRIM, Maastricht University Medical Center +, Maastricht, The Netherlands
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Mirelle J. A. J. Huijskens,
Affiliation Division of Hematology, Department of Internal Medicine, GROW—School for Oncology and Developmental Biology, Maastricht University Medical Center +, Maastricht, The Netherlands
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Birgit L. M. G. Senden-Gijsbers,
Affiliation Division of Hematology, Department of Internal Medicine, GROW—School for Oncology and Developmental Biology, Maastricht University Medical Center +, Maastricht, The Netherlands
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Melanie C. A. Schnijderberg,
Affiliation Division of Hematology, Department of Internal Medicine, GROW—School for Oncology and Developmental Biology, Maastricht University Medical Center +, Maastricht, The Netherlands
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Boudewijn Brans,
Affiliation Division of Nuclear Medicine, Department of Internal Medicine, School of NUTRIM, Maastricht University Medical Center +, Maastricht, The Netherlands
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Ludwig J. Dubois,
Affiliation MaastRO Laboratory, Department of Radiation Oncology, GROW—School for Oncology and Developmental Biology, Maastricht University Medical Center +, Maastricht, The Netherlands
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Philippe Lambin,
Affiliation MaastRO Laboratory, Department of Radiation Oncology, GROW—School for Oncology and Developmental Biology, Maastricht University Medical Center +, Maastricht, The Netherlands
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Marijke De Saint-Hubert,
Affiliation Division of Nuclear Medicine, Department of Internal Medicine, School of NUTRIM, Maastricht University Medical Center +, Maastricht, The Netherlands
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Wilfred T. V. Germeraad,
Affiliations Division of Hematology, Department of Internal Medicine, GROW—School for Oncology and Developmental Biology, Maastricht University Medical Center +, Maastricht, The Netherlands, CiMaas BV, Maastricht, The Netherlands
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Marcel G. J. Tilanus,
Affiliation Tissue Typing Laboratory, Department of Transplantation Immunology, GROW—School for Oncology and Developmental Biology, Maastricht University Medical Center +, Maastricht, The Netherlands
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Felix M. Mottaghy,
Affiliation Division of Nuclear Medicine, Department of Internal Medicine, School of NUTRIM, Maastricht University Medical Center +, Maastricht, The Netherlands
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Gerard M. J. Bos ,
Contributed equally to this work with: Gerard M. J. Bos, Joris Vanderlocht
Affiliations Division of Hematology, Department of Internal Medicine, GROW—School for Oncology and Developmental Biology, Maastricht University Medical Center +, Maastricht, The Netherlands, CiMaas BV, Maastricht, The Netherlands
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Joris Vanderlocht
Contributed equally to this work with: Gerard M. J. Bos, Joris Vanderlocht
* E-mail: joris.vanderlocht@mumc.nl
Affiliation Tissue Typing Laboratory, Department of Transplantation Immunology, GROW—School for Oncology and Developmental Biology, Maastricht University Medical Center +, Maastricht, The Netherlands
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Fractionated Radiotherapy with 3 x 8 Gy Induces Systemic Anti-Tumour Responses and Abscopal Tumour Inhibition without Modulating the Humoral Anti-Tumour Response
- Thomas H. P. M. Habets,
- Tammy Oth,
- Ans W. Houben,
- Mirelle J. A. J. Huijskens,
- Birgit L. M. G. Senden-Gijsbers,
- Melanie C. A. Schnijderberg,
- Boudewijn Brans,
- Ludwig J. Dubois,
- Philippe Lambin,
- Marijke De Saint-Hubert
- Published: July 18, 2016
- https://doi.org/10.1371/journal.pone.0159515