AMPK Mediates Glucocorticoids Stress-Induced Downregulation of the Glucocorticoid Receptor in Cultured Rat Prefrontal Cortical Astrocytes

Shi-Ying Yuan; Jue Liu; Jun Zhou; Wei Lu; Hai-Yun Zhou; Li-Hong Long; Zhuang-Li Hu; Lan Ni; Yi Wang; Jian-Guo Chen; Fang Wang

doi:10.1371/journal.pone.0159513

Loading metrics

Open Access

Peer-reviewed

Research Article

AMPK Mediates Glucocorticoids Stress-Induced Downregulation of the Glucocorticoid Receptor in Cultured Rat Prefrontal Cortical Astrocytes

Shi-Ying Yuan ,

Contributed equally to this work with: Shi-Ying Yuan, Jue Liu, Jun Zhou

Affiliation Department of Pharmacology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
⨯
Jue Liu ,

Contributed equally to this work with: Shi-Ying Yuan, Jue Liu, Jun Zhou

Affiliation Department of Pharmacy, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
⨯
Jun Zhou ,

Contributed equally to this work with: Shi-Ying Yuan, Jue Liu, Jun Zhou

Affiliation Department of Pharmacology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
⨯
Wei Lu,

Affiliation Department of Pharmacology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
⨯
Hai-Yun Zhou,

Affiliation Department of Pharmacology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
⨯
Li-Hong Long,

Affiliations Department of Pharmacology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China, Key Laboratory of Neurological Diseases (HUST), Ministry of Education of China, Wuhan, Hubei, China, The Key Laboratory for Drug Target Researches and Pharmacodynamic Evaluation of Hubei Province, Wuhan, China, The Institute of Brain Research, Huazhong University of Science and Technology, Wuhan, China
⨯
Zhuang-Li Hu,

Affiliations Department of Pharmacology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China, Key Laboratory of Neurological Diseases (HUST), Ministry of Education of China, Wuhan, Hubei, China, The Key Laboratory for Drug Target Researches and Pharmacodynamic Evaluation of Hubei Province, Wuhan, China, The Institute of Brain Research, Huazhong University of Science and Technology, Wuhan, China
⨯
Lan Ni,

Affiliations Department of Pharmacology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China, Key Laboratory of Neurological Diseases (HUST), Ministry of Education of China, Wuhan, Hubei, China, The Key Laboratory for Drug Target Researches and Pharmacodynamic Evaluation of Hubei Province, Wuhan, China, The Institute of Brain Research, Huazhong University of Science and Technology, Wuhan, China
⨯
Yi Wang,

Affiliation Department of Pharmacy, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
⨯
Jian-Guo Chen,

Affiliations Department of Pharmacology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China, Key Laboratory of Neurological Diseases (HUST), Ministry of Education of China, Wuhan, Hubei, China, The Key Laboratory for Drug Target Researches and Pharmacodynamic Evaluation of Hubei Province, Wuhan, China, The Institute of Brain Research, Huazhong University of Science and Technology, Wuhan, China
⨯
Fang Wang

* E-mail: wangfangtj0322@163.com

Affiliations Department of Pharmacology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China, Key Laboratory of Neurological Diseases (HUST), Ministry of Education of China, Wuhan, Hubei, China, The Key Laboratory for Drug Target Researches and Pharmacodynamic Evaluation of Hubei Province, Wuhan, China, The Institute of Brain Research, Huazhong University of Science and Technology, Wuhan, China
⨯

AMPK Mediates Glucocorticoids Stress-Induced Downregulation of the Glucocorticoid Receptor in Cultured Rat Prefrontal Cortical Astrocytes

Shi-Ying Yuan,
Jue Liu,
Jun Zhou,
Wei Lu,
Hai-Yun Zhou,
Li-Hong Long,
Zhuang-Li Hu,
Lan Ni,
Yi Wang,
Jian-Guo Chen

Published: August 11, 2016
https://doi.org/10.1371/journal.pone.0159513

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Astrocytes
Is the Subject Area "Astrocytes" applicable to this article?

Thanks for your feedback.
Phosphorylation
Is the Subject Area "Phosphorylation" applicable to this article?

Thanks for your feedback.
Rats
Is the Subject Area "Rats" applicable to this article?

Thanks for your feedback.
Psychological stress
Is the Subject Area "Psychological stress" applicable to this article?

Thanks for your feedback.
Depression
Is the Subject Area "Depression" applicable to this article?

Thanks for your feedback.
Prefrontal cortex
Is the Subject Area "Prefrontal cortex" applicable to this article?

Thanks for your feedback.
Drug administration
Is the Subject Area "Drug administration" applicable to this article?

Thanks for your feedback.
Swimming
Is the Subject Area "Swimming" applicable to this article?

Thanks for your feedback.