Inflammatory Stress Sensitizes the Liver to Atorvastatin-Induced Injury in ApoE-/- Mice

Wei Wu; Lei Zhao; Ping Yang; Wei Zhou; Beibei Li; John F. Moorhead; Zac Varghese; Xiong Z. Ruan; Yaxi Chen

doi:10.1371/journal.pone.0159512

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Open Access

Peer-reviewed

Research Article

Inflammatory Stress Sensitizes the Liver to Atorvastatin-Induced Injury in ApoE-/- Mice

Wei Wu,

Affiliation Center for Lipid Research & Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, Department of Infectious Diseases, the Second Affiliated Hospital, Chongqing Medical University, Chongqing, China
⨯
Lei Zhao,

Affiliation Center for Lipid Research & Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, Department of Infectious Diseases, the Second Affiliated Hospital, Chongqing Medical University, Chongqing, China
⨯
Ping Yang,

Affiliation Center for Lipid Research & Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, Department of Infectious Diseases, the Second Affiliated Hospital, Chongqing Medical University, Chongqing, China
⨯
Wei Zhou,

Affiliation Center for Lipid Research & Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, Department of Infectious Diseases, the Second Affiliated Hospital, Chongqing Medical University, Chongqing, China
⨯
Beibei Li,

Affiliation Center for Lipid Research & Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, Department of Infectious Diseases, the Second Affiliated Hospital, Chongqing Medical University, Chongqing, China
⨯
John F. Moorhead,

Affiliation John Moorhead Research Laboratory, Center for Nephrology, University College London Medical School, Royal Free Campus, University College London, London, United Kingdom
⨯
Zac Varghese,

Affiliation John Moorhead Research Laboratory, Center for Nephrology, University College London Medical School, Royal Free Campus, University College London, London, United Kingdom
⨯
Xiong Z. Ruan ,

* E-mail: chenyaxi@cqmu.edu.cn (YC); x.ruan@ucl.ac.uk (XZR)

Affiliations Center for Lipid Research & Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, Department of Infectious Diseases, the Second Affiliated Hospital, Chongqing Medical University, Chongqing, China, The Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases (CCID), Zhejiang University, Hangzhou, China, John Moorhead Research Laboratory, Center for Nephrology, University College London Medical School, Royal Free Campus, University College London, London, United Kingdom
⨯
Yaxi Chen

* E-mail: chenyaxi@cqmu.edu.cn (YC); x.ruan@ucl.ac.uk (XZR)

Affiliation Center for Lipid Research & Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, Department of Infectious Diseases, the Second Affiliated Hospital, Chongqing Medical University, Chongqing, China
⨯

Inflammatory Stress Sensitizes the Liver to Atorvastatin-Induced Injury in ApoE-/- Mice

Wei Wu,
Lei Zhao,
Ping Yang,
Wei Zhou,
Beibei Li,
John F. Moorhead,
Zac Varghese,
Xiong Z. Ruan,
Yaxi Chen

Published: July 18, 2016
https://doi.org/10.1371/journal.pone.0159512

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