3D Visualization of the Temporal and Spatial Spread of Tau Pathology Reveals Extensive Sites of Tau Accumulation Associated with Neuronal Loss and Recognition Memory Deficit in Aged Tau Transgenic Mice

Hongjun Fu; S. Abid Hussaini; Susanne Wegmann; Caterina Profaci; Jacob D. Daniels; Mathieu Herman; Sheina Emrani; Helen Y. Figueroa; Bradley T. Hyman; Peter Davies; Karen E. Duff

doi:10.1371/journal.pone.0159463

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Research Article

3D Visualization of the Temporal and Spatial Spread of Tau Pathology Reveals Extensive Sites of Tau Accumulation Associated with Neuronal Loss and Recognition Memory Deficit in Aged Tau Transgenic Mice

Hongjun Fu,

Affiliations Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Medical Center, New York, New York, United States of America, Department of Pathology and Cell Biology, Columbia University Medical Center, New York, New York, United States of America
⨯
S. Abid Hussaini,

Affiliations Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Medical Center, New York, New York, United States of America, Department of Pathology and Cell Biology, Columbia University Medical Center, New York, New York, United States of America
⨯
Susanne Wegmann,

Affiliation Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, United States of America
⨯
Caterina Profaci,

Affiliations Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Medical Center, New York, New York, United States of America, Department of Pathology and Cell Biology, Columbia University Medical Center, New York, New York, United States of America
⨯
Jacob D. Daniels,

Affiliations Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Medical Center, New York, New York, United States of America, Department of Pathology and Cell Biology, Columbia University Medical Center, New York, New York, United States of America
⨯
Mathieu Herman,

Affiliations Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Medical Center, New York, New York, United States of America, Department of Pathology and Cell Biology, Columbia University Medical Center, New York, New York, United States of America
⨯
Sheina Emrani,

Affiliations Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Medical Center, New York, New York, United States of America, Department of Pathology and Cell Biology, Columbia University Medical Center, New York, New York, United States of America
⨯
Helen Y. Figueroa,

Affiliations Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Medical Center, New York, New York, United States of America, Department of Pathology and Cell Biology, Columbia University Medical Center, New York, New York, United States of America
⨯
Bradley T. Hyman,

Affiliation Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, United States of America
⨯
Peter Davies,

Affiliation Litwin-Zucker Center for Research in Alzheimer's Disease, Feinstein Institute for Medical Research, North Shore/LIJ Health System, Manhasset, New York, United States of America
⨯
Karen E. Duff

* E-mail: ked2115@cumc.columbia.edu

Affiliations Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Medical Center, New York, New York, United States of America, Department of Pathology and Cell Biology, Columbia University Medical Center, New York, New York, United States of America
⨯

3D Visualization of the Temporal and Spatial Spread of Tau Pathology Reveals Extensive Sites of Tau Accumulation Associated with Neuronal Loss and Recognition Memory Deficit in Aged Tau Transgenic Mice

Hongjun Fu,
S. Abid Hussaini,
Susanne Wegmann,
Caterina Profaci,
Jacob D. Daniels,
Mathieu Herman,
Sheina Emrani,
Helen Y. Figueroa,
Bradley T. Hyman,
Peter Davies

Published: July 28, 2016
https://doi.org/10.1371/journal.pone.0159463

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