Establishment of a Predictive In Vitro Assay for Assessment of the Hepatotoxic Potential of Oligonucleotide Drugs

Sabine Sewing; Franziska Boess; Annie Moisan; Cristina Bertinetti-Lapatki; Tanja Minz; Maj Hedtjaern; Yann Tessier; Franz Schuler; Thomas Singer; Adrian B. Roth

doi:10.1371/journal.pone.0159431

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Open Access

Peer-reviewed

Research Article

Establishment of a Predictive In Vitro Assay for Assessment of the Hepatotoxic Potential of Oligonucleotide Drugs

Sabine Sewing ,

* E-mail: sabine.sewing@roche.com

Affiliation Roche Pharmaceutical Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Basel, Switzerland
⨯
Franziska Boess,

Affiliation Roche Pharmaceutical Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Basel, Switzerland
⨯
Annie Moisan,

Affiliation Roche Pharmaceutical Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Basel, Switzerland
⨯
Cristina Bertinetti-Lapatki,

Affiliation Roche Pharmaceutical Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Basel, Switzerland
⨯
Tanja Minz,

Affiliation Roche Pharmaceutical Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Basel, Switzerland
⨯
Maj Hedtjaern,

Affiliation Roche Pharmaceutical Research and Early Development, Therapeutic Modalities, Roche Innovation Center Copenhagen A/S, Hørsholm, Denmark
⨯
Yann Tessier,

Affiliation Roche Pharmaceutical Research and Early Development, Therapeutic Modalities, Roche Innovation Center Copenhagen A/S, Hørsholm, Denmark
⨯
Franz Schuler,

Affiliation Roche Pharmaceutical Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Basel, Switzerland
⨯
Thomas Singer,

Affiliation Roche Pharmaceutical Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Basel, Switzerland
⨯
Adrian B. Roth

Affiliation Roche Pharmaceutical Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Basel, Switzerland
⨯

Establishment of a Predictive In Vitro Assay for Assessment of the Hepatotoxic Potential of Oligonucleotide Drugs

Sabine Sewing,
Franziska Boess,
Annie Moisan,
Cristina Bertinetti-Lapatki,
Tanja Minz,
Maj Hedtjaern,
Yann Tessier,
Franz Schuler,
Thomas Singer,
Adrian B. Roth

Published: July 21, 2016
https://doi.org/10.1371/journal.pone.0159431

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Hepatocytes
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Toxicity
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Oligonucleotides
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Albumins
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