Non-Invasive Prenatal Diagnosis of Lethal Skeletal Dysplasia by Targeted Capture Sequencing of Maternal Plasma

Shan Dan; Yuan Yuan; Yaoshen Wang; Chao Chen; Changxin Gao; Song Yu; Yan Liu; Wei Song; Asan; Hongmei Zhu; Ling Yang; Hongmei Deng; Yue Su; Xin Yi

doi:10.1371/journal.pone.0159355

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Open Access

Peer-reviewed

Research Article

Non-Invasive Prenatal Diagnosis of Lethal Skeletal Dysplasia by Targeted Capture Sequencing of Maternal Plasma

Shan Dan ,

Contributed equally to this work with: Shan Dan, Yuan Yuan

* E-mail: sd_bao@sina.com (SD); yusong_bogh@sina.com (YS)

Affiliation Department of Perinatal Medicine, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China
⨯
Yuan Yuan ,

Contributed equally to this work with: Shan Dan, Yuan Yuan

Affiliations Binhai Genomics Institute, BGI-Tianjin, BGI-Shenzhen, Tianjin, China, Tianjin Translational Genomics Centre, BGI-Tianjin, BGI-Shenzhen, Tianjin, China, BGI-Shenzhen, Shenzhen, China
⨯
Yaoshen Wang,

Affiliations Binhai Genomics Institute, BGI-Tianjin, BGI-Shenzhen, Tianjin, China, Tianjin Translational Genomics Centre, BGI-Tianjin, BGI-Shenzhen, Tianjin, China, BGI-Shenzhen, Shenzhen, China
⨯
Chao Chen,

Affiliations Binhai Genomics Institute, BGI-Tianjin, BGI-Shenzhen, Tianjin, China, Tianjin Translational Genomics Centre, BGI-Tianjin, BGI-Shenzhen, Tianjin, China, BGI-Shenzhen, Shenzhen, China
⨯
Changxin Gao,

Affiliations Binhai Genomics Institute, BGI-Tianjin, BGI-Shenzhen, Tianjin, China, Tianjin Translational Genomics Centre, BGI-Tianjin, BGI-Shenzhen, Tianjin, China, BGI-Shenzhen, Shenzhen, China
⨯
Song Yu,

Affiliation Department of Perinatal Medicine, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China
⨯
Yan Liu,

Affiliation Department of Perinatal Medicine, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China
⨯
Wei Song,

Affiliation Department of Perinatal Medicine, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China
⨯
Asan,

Affiliations Binhai Genomics Institute, BGI-Tianjin, BGI-Shenzhen, Tianjin, China, Tianjin Translational Genomics Centre, BGI-Tianjin, BGI-Shenzhen, Tianjin, China, BGI-Shenzhen, Shenzhen, China
⨯
Hongmei Zhu,

Affiliations Binhai Genomics Institute, BGI-Tianjin, BGI-Shenzhen, Tianjin, China, Tianjin Translational Genomics Centre, BGI-Tianjin, BGI-Shenzhen, Tianjin, China, BGI-Shenzhen, Shenzhen, China
⨯
Ling Yang,

Affiliations Binhai Genomics Institute, BGI-Tianjin, BGI-Shenzhen, Tianjin, China, Tianjin Translational Genomics Centre, BGI-Tianjin, BGI-Shenzhen, Tianjin, China, BGI-Shenzhen, Shenzhen, China
⨯
Hongmei Deng,

Affiliation Department of Perinatal Medicine, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China
⨯
Yue Su ,

* E-mail: sd_bao@sina.com (SD); yusong_bogh@sina.com (YS)

Affiliation Department of Perinatal Medicine, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China
⨯
Xin Yi

Affiliations Binhai Genomics Institute, BGI-Tianjin, BGI-Shenzhen, Tianjin, China, Tianjin Translational Genomics Centre, BGI-Tianjin, BGI-Shenzhen, Tianjin, China, BGI-Shenzhen, Shenzhen, China, Guangzhou Key Laboratory of Cancer Trans-Omics Research (GZ2012, NO348), BGI-Guangzhou, BGI-Shenzhen, Guangzhou, China
⨯

Non-Invasive Prenatal Diagnosis of Lethal Skeletal Dysplasia by Targeted Capture Sequencing of Maternal Plasma

Shan Dan,
Yuan Yuan,
Yaoshen Wang,
Chao Chen,
Changxin Gao,
Song Yu,
Yan Liu,
Wei Song,
Asan,
Hongmei Zhu

Published: July 19, 2016
https://doi.org/10.1371/journal.pone.0159355

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