Disulfide-Trapping Identifies a New, Effective Chemical Probe for Activating the Nuclear Receptor Human LRH-1 (NR5A2)

• Felipe de Jesus Cortez,

  Affiliation Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California 94158, United States of America

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• Miyuki Suzawa,

  Affiliation Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, California 94158, United States of America

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• Sam Irvy,

  Affiliation Chemistry and Chemical Biology Graduate Program, University of California San Francisco, San Francisco, California 94158, United States of America

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• John M. Bruning,

  Affiliation Pharmaceutical Sciences and Pharmacogenomics Graduate Program, University of California San Francisco, San Francisco, California 94158, United States of America

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• Elena Sablin,

  Affiliation Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California 94158, United States of America

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• Matthew P. Jacobson,

  Affiliation Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California 94158, United States of America

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• Robert J. Fletterick,

  Affiliation Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California 94158, United States of America

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• Holly A. Ingraham ,

  * E-mail: holly.ingraham@ucsf.edu (HAI); pamela.england@ucsf.edu (PME)

  Affiliation Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, California 94158, United States of America

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• Pamela M. England

  * E-mail: holly.ingraham@ucsf.edu (HAI); pamela.england@ucsf.edu (PME)

  Affiliations Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California 94158, United States of America, Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, California 94158, United States of America

  http://orcid.org/0000-0002-2308-1048

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