Sprouty2 Suppresses Epithelial-Mesenchymal Transition of Human Lens Epithelial Cells through Blockade of Smad2 and ERK1/2 Pathways

Xuhua Tan; Yi Zhu; Chuan Chen; Xiaoyun Chen; Yingyan Qin; Bo Qu; Lixia Luo; Haotian Lin; Mingxing Wu; Weirong Chen; Yizhi Liu

doi:10.1371/journal.pone.0159275

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Open Access

Peer-reviewed

Research Article

Sprouty2 Suppresses Epithelial-Mesenchymal Transition of Human Lens Epithelial Cells through Blockade of Smad2 and ERK1/2 Pathways

Xuhua Tan ,

Contributed equally to this work with: Xuhua Tan, Yi Zhu

Affiliation State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, Guangdong, China
⨯
Yi Zhu ,

Contributed equally to this work with: Xuhua Tan, Yi Zhu

Affiliation State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, Guangdong, China
⨯
Chuan Chen,

Affiliation State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, Guangdong, China
⨯
Xiaoyun Chen,

Affiliation State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, Guangdong, China
⨯
Yingyan Qin,

Affiliation State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, Guangdong, China
⨯
Bo Qu,

Affiliation State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, Guangdong, China
⨯
Lixia Luo,

Affiliation State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, Guangdong, China
⨯
Haotian Lin,

Affiliation State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, Guangdong, China
⨯
Mingxing Wu,

Affiliation State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, Guangdong, China
⨯
Weirong Chen,

Affiliation State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, Guangdong, China
⨯
Yizhi Liu

* E-mail: yizhi_liu@aliyun.com

Affiliation State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, Guangdong, China
⨯

Sprouty2 Suppresses Epithelial-Mesenchymal Transition of Human Lens Epithelial Cells through Blockade of Smad2 and ERK1/2 Pathways

Xuhua Tan,
Yi Zhu,
Chuan Chen,
Xiaoyun Chen,
Yingyan Qin,
Bo Qu,
Lixia Luo,
Haotian Lin,
Mingxing Wu,
Weirong Chen

Published: July 14, 2016
https://doi.org/10.1371/journal.pone.0159275

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SMAD signaling
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Phosphorylation
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Transfection
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Small interfering RNA
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Signal inhibition
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Epithelial cells
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Optical lenses
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