Autologous Bone Marrow-Derived Mesenchymal Stem Cells Modulate Molecular Markers of Inflammation in Dogs with Cruciate Ligament Rupture

Peter Muir; Eric C. Hans; Molly Racette; Nicola Volstad; Susannah J. Sample; Caitlin Heaton; Gerianne Holzman; Susan L. Schaefer; Debra D. Bloom; Jason A. Bleedorn; Zhengling Hao; Ermias Amene; M. Suresh; Peiman Hematti

doi:10.1371/journal.pone.0159095

Loading metrics

Open Access

Peer-reviewed

Research Article

Autologous Bone Marrow-Derived Mesenchymal Stem Cells Modulate Molecular Markers of Inflammation in Dogs with Cruciate Ligament Rupture

Peter Muir ,

* E-mail: peter.muir@wisc.edu

Affiliation Comparative Orthopaedic Research Laboratory, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, 53706, United States of America
⨯
Eric C. Hans,

Affiliation Comparative Orthopaedic Research Laboratory, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, 53706, United States of America
⨯
Molly Racette,

Affiliation Comparative Orthopaedic Research Laboratory, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, 53706, United States of America
⨯
Nicola Volstad,

Affiliation Comparative Orthopaedic Research Laboratory, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, 53706, United States of America
⨯
Susannah J. Sample,

Affiliations Comparative Orthopaedic Research Laboratory, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, 53706, United States of America, Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, 53706, United States of America
⨯
Caitlin Heaton,

Affiliation Comparative Orthopaedic Research Laboratory, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, 53706, United States of America
⨯
Gerianne Holzman,

Affiliation UW Veterinary Care Hospital, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America
⨯
Susan L. Schaefer,

Affiliation Comparative Orthopaedic Research Laboratory, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, 53706, United States of America
⨯
Debra D. Bloom,

Affiliation Department of Medicine, School of Medicine & Public Health, University of Wisconsin-Madison, Madison, Wisconsin, 53705, United States of America
⨯
Jason A. Bleedorn,

Affiliation Comparative Orthopaedic Research Laboratory, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, 53706, United States of America
⨯
Zhengling Hao,

Affiliation Comparative Orthopaedic Research Laboratory, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, 53706, United States of America
⨯
Ermias Amene,

Affiliation Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, 53706, United States of America
⨯
M. Suresh,

Affiliation Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, 53706, United States of America
⨯
Peiman Hematti

Affiliations Department of Medicine, School of Medicine & Public Health, University of Wisconsin-Madison, Madison, Wisconsin, 53705, United States of America, University of Wisconsin Carbone Cancer Center, Madison, Wisconsin, 53705, United States of America
⨯

Autologous Bone Marrow-Derived Mesenchymal Stem Cells Modulate Molecular Markers of Inflammation in Dogs with Cruciate Ligament Rupture

Peter Muir,
Eric C. Hans,
Molly Racette,
Nicola Volstad,
Susannah J. Sample,
Caitlin Heaton,
Gerianne Holzman,
Susan L. Schaefer,
Debra D. Bloom,
Jason A. Bleedorn

Published: August 30, 2016
https://doi.org/10.1371/journal.pone.0159095

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Dogs
Is the Subject Area "Dogs" applicable to this article?

Thanks for your feedback.
Veterinary diagnostics
Is the Subject Area "Veterinary diagnostics" applicable to this article?

Thanks for your feedback.
Synovial fluid
Is the Subject Area "Synovial fluid" applicable to this article?

Thanks for your feedback.
Cytokines
Is the Subject Area "Cytokines" applicable to this article?

Thanks for your feedback.
Ligaments
Is the Subject Area "Ligaments" applicable to this article?

Thanks for your feedback.
C-reactive proteins
Is the Subject Area "C-reactive proteins" applicable to this article?

Thanks for your feedback.
T cells
Is the Subject Area "T cells" applicable to this article?

Thanks for your feedback.
Inflammation
Is the Subject Area "Inflammation" applicable to this article?

Thanks for your feedback.