The Relationship between Common Genetic Markers of Breast Cancer Risk and Chemotherapy-Induced Toxicity: A Case-Control Study

Leila Dorling; Siddhartha Kar; Kyriaki Michailidou; Louise Hiller; Anne-Laure Vallier; Susan Ingle; Richard Hardy; Sarah J. Bowden; Janet A. Dunn; Chris Twelves; Christopher J. Poole; Carlos Caldas; Helena M. Earl; Paul D. P. Pharoah; Jean E. Abraham

doi:10.1371/journal.pone.0158984

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Open Access

Peer-reviewed

Research Article

The Relationship between Common Genetic Markers of Breast Cancer Risk and Chemotherapy-Induced Toxicity: A Case-Control Study

Leila Dorling ,

* E-mail: ld429@medschl.cam.ac.uk

Affiliation Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Cambridge, United Kingdom

http://orcid.org/0000-0003-1214-8080

⨯
Siddhartha Kar,

Affiliation Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Cambridge, United Kingdom
⨯
Kyriaki Michailidou,

Affiliations Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Cambridge, United Kingdom, Department of Electron Microscopy/Molecular Pathology, Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus
⨯
Louise Hiller,

Affiliation Warwick Clinical Trials Unit, University of Warwick, Coventry, United Kingdom
⨯
Anne-Laure Vallier,

Affiliation Cambridge Breast Unit and NIHR Cambridge Biomedical Research Centre, University of Cambridge NHS Foundation Hospitals, Cambridge, United Kingdom
⨯
Susan Ingle,

Affiliation Cambridge Breast Unit and NIHR Cambridge Biomedical Research Centre, University of Cambridge NHS Foundation Hospitals, Cambridge, United Kingdom
⨯
Richard Hardy,

Affiliation Cambridge Breast Unit and NIHR Cambridge Biomedical Research Centre, University of Cambridge NHS Foundation Hospitals, Cambridge, United Kingdom
⨯
Sarah J. Bowden,

Affiliation Cancer Research UK Clinical Trials Unit (CRCTU), University of Birmingham, Birmingham, United Kingdom
⨯
Janet A. Dunn,

Affiliation Warwick Clinical Trials Unit, University of Warwick, Coventry, United Kingdom
⨯
Chris Twelves,

Affiliation Leeds Institute of Cancer and Pathology and Leeds Experimental Cancer Medical Centre, Leeds, United Kingdom
⨯
Christopher J. Poole,

Affiliation Warwick Clinical Trials Unit, University of Warwick, Coventry, United Kingdom
⨯
Carlos Caldas,

Affiliations Cambridge Breast Unit and NIHR Cambridge Biomedical Research Centre, University of Cambridge NHS Foundation Hospitals, Cambridge, United Kingdom, Cambridge Experimental Cancer Medicine Centre, Cambridge, United Kingdom, Cancer Research UK Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge, United Kingdom
⨯
Helena M. Earl,

Affiliations Cambridge Breast Unit and NIHR Cambridge Biomedical Research Centre, University of Cambridge NHS Foundation Hospitals, Cambridge, United Kingdom, Cambridge Experimental Cancer Medicine Centre, Cambridge, United Kingdom
⨯
Paul D. P. Pharoah,

Affiliation Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Cambridge, United Kingdom
⨯
Jean E. Abraham

Affiliations Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Cambridge, United Kingdom, Cambridge Breast Unit and NIHR Cambridge Biomedical Research Centre, University of Cambridge NHS Foundation Hospitals, Cambridge, United Kingdom, Cambridge Experimental Cancer Medicine Centre, Cambridge, United Kingdom
⨯

The Relationship between Common Genetic Markers of Breast Cancer Risk and Chemotherapy-Induced Toxicity: A Case-Control Study

Leila Dorling,
Siddhartha Kar,
Kyriaki Michailidou,
Louise Hiller,
Anne-Laure Vallier,
Susan Ingle,
Richard Hardy,
Sarah J. Bowden,
Janet A. Dunn,
Chris Twelves

Published: July 8, 2016
https://doi.org/10.1371/journal.pone.0158984

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