Preclinical Evidence of Anti-Tumor Activity Induced by EZH2 Inhibition in Human Models of Synovial Sarcoma

Satoshi Kawano; Alexandra R. Grassian; Masumi Tsuda; Sarah K. Knutson; Natalie M. Warholic; Galina Kuznetsov; Shanqin Xu; Yonghong Xiao; Roy M. Pollock; Jesse S. Smith; Kevin K. Kuntz; Scott Ribich; Yukinori Minoshima; Junji Matsui; Robert A. Copeland; Shinya Tanaka; Heike Keilhack

doi:10.1371/journal.pone.0158888

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Open Access

Peer-reviewed

Research Article

Preclinical Evidence of Anti-Tumor Activity Induced by EZH2 Inhibition in Human Models of Synovial Sarcoma

Satoshi Kawano ,

Contributed equally to this work with: Satoshi Kawano, Alexandra R. Grassian

Affiliation Eisai Co., Ltd., Tsukuba, Ibaraki, Japan
⨯
Alexandra R. Grassian ,

Contributed equally to this work with: Satoshi Kawano, Alexandra R. Grassian

* E-mail: agrassian@epizyme.com (ARG); sribich@epizyme.com (SR)

Affiliation Epizyme Inc., Cambridge, Massachusetts, United States of America
⨯
Masumi Tsuda,

Affiliation Department of Cancer Pathology, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan
⨯
Sarah K. Knutson,

Affiliation Epizyme Inc., Cambridge, Massachusetts, United States of America
⨯
Natalie M. Warholic,

Affiliation Epizyme Inc., Cambridge, Massachusetts, United States of America
⨯
Galina Kuznetsov,

Affiliation Eisai Inc., Andover, Massachusetts, United States of America
⨯
Shanqin Xu,

Affiliation Eisai Inc., Andover, Massachusetts, United States of America
⨯
Yonghong Xiao,

Affiliation Epizyme Inc., Cambridge, Massachusetts, United States of America
⨯
Roy M. Pollock,

Affiliation Epizyme Inc., Cambridge, Massachusetts, United States of America
⨯
Jesse S. Smith,

Affiliation Epizyme Inc., Cambridge, Massachusetts, United States of America
⨯
Kevin K. Kuntz,

Affiliation Epizyme Inc., Cambridge, Massachusetts, United States of America
⨯
Scott Ribich ,

* E-mail: agrassian@epizyme.com (ARG); sribich@epizyme.com (SR)

Affiliation Epizyme Inc., Cambridge, Massachusetts, United States of America
⨯
Yukinori Minoshima,

Affiliation Eisai Co., Ltd., Tsukuba, Ibaraki, Japan
⨯
Junji Matsui,

Affiliation Eisai Co., Ltd., Tsukuba, Ibaraki, Japan
⨯
Robert A. Copeland,

Affiliation Epizyme Inc., Cambridge, Massachusetts, United States of America
⨯
Shinya Tanaka,

Affiliation Department of Cancer Pathology, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan
⨯
[ ... ],
Heike Keilhack

Affiliation Epizyme Inc., Cambridge, Massachusetts, United States of America
⨯
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Preclinical Evidence of Anti-Tumor Activity Induced by EZH2 Inhibition in Human Models of Synovial Sarcoma

Satoshi Kawano,
Alexandra R. Grassian,
Masumi Tsuda,
Sarah K. Knutson,
Natalie M. Warholic,
Galina Kuznetsov,
Shanqin Xu,
Yonghong Xiao,
Roy M. Pollock,
Jesse S. Smith

Published: July 8, 2016
https://doi.org/10.1371/journal.pone.0158888

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