Regulation of Thrombin-Induced Lung Endothelial Cell Barrier Disruption by Protein Kinase C Delta

Lishi Xie; Eddie T. Chiang; Xiaomin Wu; Gabriel T. Kelly; Prasad Kanteti; Patrick A. Singleton; Sara M. Camp; Tingting Zhou; Steven M. Dudek; Viswanathan Natarajan; Ting Wang; Steven M. Black; Joe G. N. Garcia; Jeffrey R. Jacobson

doi:10.1371/journal.pone.0158865

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Peer-reviewed

Research Article

Regulation of Thrombin-Induced Lung Endothelial Cell Barrier Disruption by Protein Kinase C Delta

Lishi Xie,

Affiliations Institute for Personalized Respiratory Medicine, University of Illinois at Chicago, Chicago, Illinois, United States of America, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, United States of America
⨯
Eddie T. Chiang,

Affiliation Department of Medicine and Arizona Respiratory Center, University of Arizona, Tucson, Arizona, United States of America
⨯
Xiaomin Wu,

Affiliation Department of Medicine and Arizona Respiratory Center, University of Arizona, Tucson, Arizona, United States of America

http://orcid.org/0000-0002-8792-0584

⨯
Gabriel T. Kelly,

Affiliation Department of Medicine and Arizona Respiratory Center, University of Arizona, Tucson, Arizona, United States of America
⨯
Prasad Kanteti,

Affiliations Institute for Personalized Respiratory Medicine, University of Illinois at Chicago, Chicago, Illinois, United States of America, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, United States of America
⨯
Patrick A. Singleton,

Affiliation Department of Medicine, University of Chicago, Chicago, Illinois, United States of America
⨯
Sara M. Camp,

Affiliation Department of Medicine and Arizona Respiratory Center, University of Arizona, Tucson, Arizona, United States of America
⨯
Tingting Zhou,

Affiliations Institute for Personalized Respiratory Medicine, University of Illinois at Chicago, Chicago, Illinois, United States of America, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, United States of America
⨯
Steven M. Dudek,

Affiliations Institute for Personalized Respiratory Medicine, University of Illinois at Chicago, Chicago, Illinois, United States of America, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, United States of America
⨯
Viswanathan Natarajan,

Affiliations Institute for Personalized Respiratory Medicine, University of Illinois at Chicago, Chicago, Illinois, United States of America, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, United States of America, Department of Pharmacology, University of Illinois at Chicago, Chicago, Illinois, United States of America
⨯
Ting Wang,

Affiliation Department of Medicine and Arizona Respiratory Center, University of Arizona, Tucson, Arizona, United States of America
⨯
Steven M. Black,

Affiliation Department of Medicine and Arizona Respiratory Center, University of Arizona, Tucson, Arizona, United States of America
⨯
Joe G. N. Garcia,

Affiliations Institute for Personalized Respiratory Medicine, University of Illinois at Chicago, Chicago, Illinois, United States of America, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, United States of America, Department of Medicine and Arizona Respiratory Center, University of Arizona, Tucson, Arizona, United States of America
⨯
Jeffrey R. Jacobson

* E-mail: jrjacob@uic.edu

Affiliations Institute for Personalized Respiratory Medicine, University of Illinois at Chicago, Chicago, Illinois, United States of America, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, United States of America
⨯

Regulation of Thrombin-Induced Lung Endothelial Cell Barrier Disruption by Protein Kinase C Delta

Lishi Xie,
Eddie T. Chiang,
Xiaomin Wu,
Gabriel T. Kelly,
Prasad Kanteti,
Patrick A. Singleton,
Sara M. Camp,
Tingting Zhou,
Steven M. Dudek,
Viswanathan Natarajan

Published: July 21, 2016
https://doi.org/10.1371/journal.pone.0158865

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Thrombin
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Phosphorylation
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Small interfering RNA
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Thrombin signaling
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Guanosine triphosphatase
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Vascular permeability
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Cell disruption
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Stress signaling cascade
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