Intratracheal Administration of Mesenchymal Stem Cells Modulates Tachykinin System, Suppresses Airway Remodeling and Reduces Airway Hyperresponsiveness in an Animal Model

Konrad Urbanek; Antonella De Angelis; Giuseppe Spaziano; Elena Piegari; Maria Matteis; Donato Cappetta; Grazia Esposito; Rosa Russo; Gioia Tartaglione; Raffaele De Palma; Francesco Rossi; Bruno D’Agostino

doi:10.1371/journal.pone.0158746

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Open Access

Peer-reviewed

Research Article

Intratracheal Administration of Mesenchymal Stem Cells Modulates Tachykinin System, Suppresses Airway Remodeling and Reduces Airway Hyperresponsiveness in an Animal Model

Konrad Urbanek ,

Contributed equally to this work with: Konrad Urbanek, Antonella De Angelis

Affiliation Department of Experimental Medicine, Section of Pharmacology, Second University of Naples, Naples, Italy
⨯
Antonella De Angelis ,

Contributed equally to this work with: Konrad Urbanek, Antonella De Angelis

* E-mail: antonella.deangelis@unina2.it (AA); bruno.dagostino@unina2.it (BA)

Affiliation Department of Experimental Medicine, Section of Pharmacology, Second University of Naples, Naples, Italy
⨯
Giuseppe Spaziano,

Affiliation Department of Experimental Medicine, Section of Pharmacology, Second University of Naples, Naples, Italy
⨯
Elena Piegari,

Affiliation Department of Experimental Medicine, Section of Pharmacology, Second University of Naples, Naples, Italy
⨯
Maria Matteis,

Affiliation Department of Experimental Medicine, Section of Pharmacology, Second University of Naples, Naples, Italy
⨯
Donato Cappetta,

Affiliation Department of Experimental Medicine, Section of Pharmacology, Second University of Naples, Naples, Italy
⨯
Grazia Esposito,

Affiliation Department of Experimental Medicine, Section of Pharmacology, Second University of Naples, Naples, Italy
⨯
Rosa Russo,

Affiliation Department of Experimental Medicine, Section of Pharmacology, Second University of Naples, Naples, Italy
⨯
Gioia Tartaglione,

Affiliation Department of Experimental Medicine, Section of Pharmacology, Second University of Naples, Naples, Italy
⨯
Raffaele De Palma,

Affiliation Department of Clinical and Experimental Medicine, Second University of Naples, Naples, Italy
⨯
Francesco Rossi,

Affiliation Department of Experimental Medicine, Section of Pharmacology, Second University of Naples, Naples, Italy
⨯
Bruno D’Agostino

* E-mail: antonella.deangelis@unina2.it (AA); bruno.dagostino@unina2.it (BA)

Affiliation Department of Experimental Medicine, Section of Pharmacology, Second University of Naples, Naples, Italy
⨯

Intratracheal Administration of Mesenchymal Stem Cells Modulates Tachykinin System, Suppresses Airway Remodeling and Reduces Airway Hyperresponsiveness in an Animal Model

Konrad Urbanek,
Antonella De Angelis,
Giuseppe Spaziano,
Elena Piegari,
Maria Matteis,
Donato Cappetta,
Grazia Esposito,
Rosa Russo,
Gioia Tartaglione,
Raffaele De Palma

Published: July 19, 2016
https://doi.org/10.1371/journal.pone.0158746

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Mesenchymal stem cells
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Inflammation
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Asthma
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Cell enumeration techniques
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Smooth muscles
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Pulmonary arteries
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