Hyperglycemia Induces Cellular Hypoxia through Production of Mitochondrial ROS Followed by Suppression of Aquaporin-1

Kiminori Sada; Takeshi Nishikawa; Daisuke Kukidome; Tomoaki Yoshinaga; Nobuhiro Kajihara; Kazuhiro Sonoda; Takafumi Senokuchi; Hiroyuki Motoshima; Takeshi Matsumura; Eiichi Araki

doi:10.1371/journal.pone.0158619

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Open Access

Peer-reviewed

Research Article

Hyperglycemia Induces Cellular Hypoxia through Production of Mitochondrial ROS Followed by Suppression of Aquaporin-1

Kiminori Sada,

Affiliation Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan
⨯
Takeshi Nishikawa ,

* E-mail: t-nishikawa@kumamed.jp

Affiliations Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan, Department of Molecular Diabetology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan
⨯
Daisuke Kukidome,

Affiliation Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan
⨯
Tomoaki Yoshinaga,

Affiliation Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan
⨯
Nobuhiro Kajihara,

Affiliation Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan
⨯
Kazuhiro Sonoda,

Affiliation Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan
⨯
Takafumi Senokuchi,

Affiliations Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan, Department of Molecular Diabetology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan
⨯
Hiroyuki Motoshima,

Affiliation Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan
⨯
Takeshi Matsumura,

Affiliation Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan
⨯
Eiichi Araki

Affiliation Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan
⨯

Hyperglycemia Induces Cellular Hypoxia through Production of Mitochondrial ROS Followed by Suppression of Aquaporin-1

Kiminori Sada,
Takeshi Nishikawa,
Daisuke Kukidome,
Tomoaki Yoshinaga,
Nobuhiro Kajihara,
Kazuhiro Sonoda,
Takafumi Senokuchi,
Hiroyuki Motoshima,
Takeshi Matsumura,
Eiichi Araki

Published: July 6, 2016
https://doi.org/10.1371/journal.pone.0158619

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